AS2471907

a PET radiotracer for imaging 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)

Also Known As:

(11)C-AS2471907; (11C)-AS2471907; 11C-AS2471907; 3-(2-chlorophenyl)-4-(methyl-11 C)-5-(2-(2,4,6-trifluorophenoxy)propan-2-yl)-4H-1,2,4-triazole

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Wounds and Injuries (Trauma) 10/15/2021 - "This study used positron emission tomography (PET) to image 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a cortisol-producing enzyme, as a putative brain cortisol marker in PTSD.METHODSSixteen individuals with PTSD and 17 healthy, trauma-exposed controls (TCs) underwent PET imaging with [18F]AS2471907, a radioligand for 11β-HSD1.RESULTSPrefrontal-limbic 11β-HSD1 availability, estimated as [18F]AS2471907 volume of distribution (VT), was significantly higher in the PTSD group compared with the TC group (β = 1.16, P = 0.0057). "
2.	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 10/15/2021 - "This study used positron emission tomography (PET) to image 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a cortisol-producing enzyme, as a putative brain cortisol marker in PTSD.METHODSSixteen individuals with PTSD and 17 healthy, trauma-exposed controls (TCs) underwent PET imaging with [18F]AS2471907, a radioligand for 11β-HSD1.RESULTSPrefrontal-limbic 11β-HSD1 availability, estimated as [18F]AS2471907 volume of distribution (VT), was significantly higher in the PTSD group compared with the TC group (β = 1.16, P = 0.0057). "

1.	Oxidoreductases (Dehydrogenase)
2.	Hydrocortisone (Cortisol)
3.	Enzymes