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SARS-CoV-2 NSP1 protein

Also Known As:

NSP1 protein, SARS-CoV-2; NSP1 protein, Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV-2 leader protein

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Viral Proteins: 4250
    - Viral Nonstructural Proteins: 70
      - SARS-CoV-2 NSP1 protein: 2

Experts

1.	Klemm, Cinzia: 1 article (12/2021)
2.	Thomas, Grace Heredge: 1 article (12/2021)
3.	Thorpe, Peter H: 1 article (12/2021)
4.	Torres, Mara Teixeira: 1 article (12/2021)
5.	Wood, Henry: 1 article (12/2021)
6.	Ólafsson, Guðjón: 1 article (12/2021)
7.	Burke, James M: 1 article (11/2021)
8.	Parker, Roy: 1 article (11/2021)
9.	Perera, Rushika: 1 article (11/2021)
10.	St Clair, Laura A: 1 article (11/2021)

Related Diseases

1.	Virus Diseases (Viral Diseases) 12/06/2021 - "Specifically, we were able to show that recruiting the SARS-CoV-2 NSP1 protein to HOPS, a vesicle-docking complex, is sufficient to perturb membrane trafficking in yeast consistent with the hijacking of the endoplasmic-reticulum-Golgi intermediate compartment trafficking pathway during viral infection of mammalian cells. "
2.	COVID-19 11/01/2021 - "Lastly, nuclear-cytoplasmic transport of IFN mRNAs is inhibited during SARS-CoV-2 infection, which we propose is a consequence of widespread degradation of host cytoplasmic basal mRNAs in the early stages of SARS-CoV-2 replication by the SARS-CoV-2 Nsp1 protein, as well as the host antiviral endoribonuclease, RNase L. "

Related Drugs and Biologics

1.	Endoribonucleases
2.	Antiviral Agents (Antivirals)
3.	2-5A-dependent ribonuclease (RNase L)