SARS-CoV-2 papain-like protease

Also Known As:

papain-like protease, SARS-CoV-2; NSP3 protein, SARS-CoV-2; NSP3 protein, Severe Acute Respiratory Syndrome Coronavirus 2; PLpro protein, SARS-CoV-2; papain-like protease, Severe Acute Respiratory Syndrome Coronavirus 2

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Arya, Rimanshee: 1 article (01/2022)
2.	Hu, Yanmei: 1 article (01/2022)
3.	Jadhav, Prakash: 1 article (01/2022)
4.	Kumar, Mukesh: 1 article (01/2022)
5.	Prashar, Vishal: 1 article (01/2022)
6.	Tan, Bin: 1 article (01/2022)
7.	Tan, Haozhou: 1 article (01/2022)
8.	Wang, Jun: 1 article (01/2022)
9.	Aceves, Nathalie M: 1 article (11/2021)
10.	Compton, Jaimee R: 1 article (11/2021)

Related Diseases

1.	COVID-19 10/01/2021 - "Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like protease." 01/01/2020 - "We present a virtual screening campaign to identify covalent and non-covalent inhibitors of the SARS-CoV-2 papain-like protease (PLpro) showing potential multitarget activities (i.e., a desirable polypharmacology profile) for the COVID-19 treatment. " 11/01/2023 - "Investigation of the interactions of HSA and SARS-CoV-2 papain-like protease against eugenol for novel COVID-19 drug discovery: spectroscopic and insilico study." 01/01/2022 - "Because of the essential roles of SARS-CoV-2 papain-like protease (PLpro) in the viral polyprotein processing and suppression of host immune responses, it is a crucial target for drug discovery against COVID-19. " 01/01/2021 - "Binding affinity of Tyrocidine A and Gramicidin S with SARS-CoV-2 papain-like protease was - 13.1 kcal/mol and - 11.4 kcal/mol, respectively which might be inhibited COVID-19 by acting on the protease. "
2.	Virus Diseases (Viral Diseases) 01/01/2022 - "The SARS-CoV-2 papain-like protease (PLpro) mediates the cleavage of viral polyprotein and modulates the host's innate immune response upon viral infection, rendering it a promising antiviral drug target. "
3.	Thrombosis (Thrombus) 11/01/2021 - "Here we identify sequences cleaved by the SARS-CoV-2 papain-like protease (PLpro) in vitro within human MYH7 and MYH6 (two cardiac myosins linked to several cardiomyopathies), FOXP3 (an X-linked Treg cell transcription factor), ErbB4 (HER4), and vitamin-K-dependent plasma protein S (PROS1), an anticoagulation protein that prevents blood clots. "
4.	Neoplasms (Cancer) 01/01/2021 - "Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain Deubiquitinases."
5.	Cardiomyopathies (Cardiomyopathy) 11/01/2021 - "Here we identify sequences cleaved by the SARS-CoV-2 papain-like protease (PLpro) in vitro within human MYH7 and MYH6 (two cardiac myosins linked to several cardiomyopathies), FOXP3 (an X-linked Treg cell transcription factor), ErbB4 (HER4), and vitamin-K-dependent plasma protein S (PROS1), an anticoagulation protein that prevents blood clots. "

Related Drugs and Biologics

1.	Eugenol
2.	Polyproteins
3.	Cardiac Myosins
4.	Vitamin K
5.	Tyrocidine
6.	Transcription Factors (Transcription Factor)
7.	Proteins (Proteins, Gene)
8.	Peptide Hydrolases (Proteases)
9.	Interferon Type I
10.	Gramicidin (Gramicidin A)