SARS-CoV-2 3C-like proteinase

Also Known As:

3C-like proteinase, SARS-CoV-2; 3C-like protease, SARS-CoV-2; 3C-like proteinase protein, severe acute respiratory syndrome coronavirus 2; 3CL(pro) protein, SARS-CoV-2; M(pro) protein, 2019 novel coronavirus; M(pro) protein, severe acute respiratory syndrome coronavirus 2; NSP5 protein, SARS-Cov-2; NSP5A protein, SARS-Cov-2; NSP5A protein, Severe Acute Respiratory Syndrome Coronavirus 2; NSP5B protein, SARS-Cov-2; NSP5B protein, Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV-2 main protease

Networked: 114 relevant articles (5 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rehman, Md Tabish: 4 articles (01/2021 - 01/2020)
2.	Liu, Wenshe Ray: 3 articles (01/2022 - 12/2021)
3.	Xu, Shiqing: 3 articles (01/2022 - 12/2021)
4.	Mahmud, Shafi: 3 articles (11/2021 - 12/2020)
5.	AlAjmi, Mohamed F: 3 articles (01/2021 - 01/2020)
6.	Hussain, Afzal: 3 articles (01/2021 - 01/2020)
7.	Alugubelli, Yugendar R: 2 articles (01/2022 - 12/2021)
8.	Ma, Xinyu R: 2 articles (01/2022 - 12/2021)
9.	Ma, Yuying: 2 articles (01/2022 - 12/2021)
10.	Vatansever, Erol C: 2 articles (01/2022 - 12/2021)

Related Diseases

1.	COVID-19 01/01/2021 - "One promising treatment target for COVID-19 is SARS-CoV-2 main protease. " 01/01/2020 - "Designing of improved drugs for COVID-19: Crystal structure of SARS-CoV-2 main protease Mpro." 11/24/2023 - "In this study, machine learning was applied for predicting the SARS-CoV-2 main protease binding of Food and Drug Administration (FDA)-approved drugs to assist in the identification of potential repurposing candidates for COVID-19 treatment. " 09/15/2023 - "Phytoconstituents as potential therapeutic agents against COVID-19: a computational study on inhibition of SARS-CoV-2 main protease." 04/28/2023 - "In-silico guided design, screening, and molecular dynamic simulation studies for the identification of potential SARS-CoV-2 main protease inhibitors for the targeted treatment of COVID-19."
2.	Virus Diseases (Viral Diseases) 12/01/2021 - "SARS-CoV-2 main protease is a possible target for protection against viral infection. " 06/18/2020 - "Statins may also serve as potential SARS-CoV-2 main protease inhibitors, thereby contributing to the control of viral infection. " 01/01/2022 - "The results indicated that, Ritonavir has the highest potency to block SARS-CoV-2 main protease and human TMPRSS2, a host cell factor that aids viral infection. " 01/01/2023 - "The objective of this work was to evaluate the antiviral activity of different plant extracts available in the library of natural products of the Universidade Estadual de Maringá, by inhibiting the SARS-CoV-2 main protease (Mpro), and by preventing viral infection in a cellular model. " 10/15/2022 - "Molecular docking studies are implemented to analyse the binding energy of the BCMTP compound against standard drugs such as the crystal structure of ADP ribose phosphatase of NSP3 from SARS-CoV-2 in complex with MES and SARS-CoV-2 main protease with an unliganded active site (2019-nCoV, corona virus disease 2019, COVID-19) and found to be considered having better antiviral agents. "
3.	Infections 01/01/2023 - "The SARS-CoV-2 main protease is an essential molecule for viral replication and is often targeted by medications to treat the infection. " 01/01/2022 - "SARS-CoV-2 main protease (Mpro) involved in COVID-19 is required for maturation of the virus and infection of host cells. " 05/01/2021 - "Aminoglycosides as potential inhibitors of SARS-CoV-2 main protease: an in silico drug repurposing study on FDA-approved antiviral and anti-infection agents." 01/01/2023 - "Nirmatrelvir, an oral antiviral agent that targets a SARS-CoV-2 main protease (3CLpro), is clinically useful against infection with SARS-CoV-2 including its omicron variants. " 09/09/2023 - "The SARS-CoV-2 main protease (Mpro) is critical for the production of functional viral proteins during infection and, like many viral proteases, can also target host proteins to subvert their cellular functions. "
4.	Acquired Immunodeficiency Syndrome (AIDS) 10/06/2022 - "NMR Observation of Sulfhydryl Signals in SARS-CoV-2 Main Protease Aids Structural Studies." 01/01/2022 - "The results indicated that, Ritonavir has the highest potency to block SARS-CoV-2 main protease and human TMPRSS2, a host cell factor that aids viral infection. "
5.	Neoplasms (Cancer) 01/01/2022 - "Examples are described involving rhenium theranostics, the anti-cancer platins and the SARS-CoV-2 main protease." 09/01/2020 - "We investigated the mechanism of action for these and found that masitinib, a drug originally developed as a tyrosine-kinase inhibitor for cancer treatment, strongly inhibited the activity of the SARS-CoV-2 main protease 3CLpro. "

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)
2.	ensitrelvir
3.	Antiviral Agents (Antivirals)
4.	Enzymes
5.	Proteins (Proteins, Gene)
6.	Quercetin
7.	Protease Inhibitors (Protease Inhibitor)
8.	Papain
9.	Flavonoids
10.	Azithromycin (Zithromax)

Related Therapies and Procedures

1.	Therapeutics
2.	Precision Medicine