GS-441524 triphosphate

intracellular active metabolite of remdesivir

Also Known As:

D-altrononitrile, 2-C-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-, 6-(tetrahydrogen triphosphate); GS 441524 triphosphate; GS-441524-TP; GS-443902; GS441524 triphosphate; remdesivir triphosphate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleotides: 140
        Adenine Nucleotides: 1066
        Adenosine Triphosphate: 27668
        GS-441524 triphosphate: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Ribonucleotides: 307
    - Adenine Nucleotides: 1066
      - Adenosine Triphosphate: 27668
        GS-441524 triphosphate: 2
  - Purine Nucleotides: 140
    - Adenine Nucleotides: 1066
      - Adenosine Triphosphate: 27668
        GS-441524 triphosphate: 2

Experts

1.	Babusis, Darius: 1 article (01/2021)
2.	Cao, Huyen: 1 article (01/2021)
3.	German, Polina: 1 article (01/2021)
4.	Hansen, Peter Riis: 1 article (01/2021)
5.	Hansen, Poul Erik: 1 article (01/2021)
6.	Humeniuk, Rita: 1 article (01/2021)
7.	Jürgens, Gesche: 1 article (01/2021)
8.	Kirby, Brian J: 1 article (01/2021)
9.	Ling, John: 1 article (01/2021)
10.	Lutz, Justin D: 1 article (01/2021)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2021 - "Similarly, hypoxia and inflammation may lead to reduced expression of adenosine kinase, which is believed to convert GS-441524 to GS-441524 monophosphate, the perceived rate-limiting step in the intracellular formation of GS-441524 triphosphate. "
2.	Hypoxia (Hypoxemia) 01/01/2021 - "Similarly, hypoxia and inflammation may lead to reduced expression of adenosine kinase, which is believed to convert GS-441524 to GS-441524 monophosphate, the perceived rate-limiting step in the intracellular formation of GS-441524 triphosphate. "
3.	COVID-19 01/01/2021 - "Results showed high intracellular concentrations of GS-443902 suggestive of efficient conversion from RDV into the triphosphate form, and further supporting this clinical dosing regimen for the treatment of COVID-19. "

Related Drugs and Biologics

1.	Adenosine Kinase
2.	triphosphoric acid (triphosphate)
3.	GS-441524 monophosphate
4.	GS-441524