FND-4b

activator of adenosine monophosphate-activated kinase (AMPK) that inhibit cell cycle progression of colorectal cancer cells

Also Known As:

1-(3-chloro-4-((trifluoromethyl)thio)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Phenylurea Compounds: 1
      - FND-4b: 2
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenylurea Compounds: 1
        FND-4b: 2

Experts

1.	Evers, B Mark: 2 articles (01/2019 - 01/2019)
2.	Johnson, Jeremy: 2 articles (01/2019 - 01/2019)
3.	Liu, Chunming: 2 articles (01/2019 - 01/2019)
4.	Watt, David S: 2 articles (01/2019 - 01/2019)
5.	Rychahou, Piotr: 1 article (01/2019)
6.	Rychahou, Piotr G: 1 article (01/2019)
7.	Sinner, Heather F: 1 article (01/2019)
8.	Sviripa, Vitaliy M: 1 article (01/2019)
9.	Weiss, Heidi L: 1 article (01/2019)
10.	Zaytseva, Yekaterina Y: 1 article (01/2019)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2019 - "Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation."
2.	Neoplasms (Cancer) 01/01/2019 - "Our findings indicate that FND-4b decreases proliferation for a variety of breast cancers by activating AMPK and has notable effects on TNBC. " 01/01/2019 - "Induction of AMPK activation by N,N'-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers." 01/01/2019 - "AMP-activated protein kinase (AMPK) is a major energy regulator that suppresses tumor growth, and 1-(3-chloro-4-((trifluoromethyl)thio)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea (FND-4b) is a novel AMPK activator that inhibits growth and induces apoptosis in colon cancer. "
3.	Colonic Neoplasms (Colon Cancer) 01/01/2019 - "AMP-activated protein kinase (AMPK) is a major energy regulator that suppresses tumor growth, and 1-(3-chloro-4-((trifluoromethyl)thio)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea (FND-4b) is a novel AMPK activator that inhibits growth and induces apoptosis in colon cancer. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2019 - "The purpose of this project was to test the effects of FND-4b on AMPK activation, proliferation, and apoptosis in breast cancer with a particular emphasis on TNBC. " 01/01/2019 - "(i) Estrogen-receptor positive breast cancer (ER+BC; MCF-7, and T-47D), TNBC (MDA-MB-231 and HCC-1806), and breast cancer stem cells were treated with FND-4b for 24h. "

Related Drugs and Biologics

1.	AMP-Activated Protein Kinases
2.	Estrogen Receptors