SARS-CoV-2 ORF8 protein

Also Known As:

ORF8 protein, SARS-CoV-2; ORF8 protein, 2019 novel coronavirus; ORF8 protein, 2019-nCoV; ORF8 protein, COVID-19 virus; ORF8 protein, COVID19 virus; ORF8 protein, severe acute respiratory syndrome coronavirus 2

Networked: 5 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Viral Proteins: 4250
    - SARS-CoV-2 ORF8 protein: 5

Experts

1.	Au, Shannon Wing-Ngor: 2 articles (12/2021 - 10/2020)
2.	Kok, Kin-Hang: 2 articles (12/2021 - 10/2020)
3.	Lam, Joy-Yan: 2 articles (12/2021 - 10/2020)
4.	To, Kelvin K W: 2 articles (12/2021 - 10/2020)
5.	Wang, Xiaohui: 2 articles (12/2021 - 10/2020)
6.	Yuen, Kwok-Yung: 2 articles (12/2021 - 10/2020)
7.	Al-Gareeb, Ali I: 1 article (01/2022)
8.	Al-Kuraishy, Hayder M: 1 article (01/2022)
9.	El-Saber Batiha, Gaber: 1 article (01/2022)
10.	Onohuean, Hope: 1 article (01/2022)

Related Diseases

1.	COVID-19 10/20/2020 - "Accurate Diagnosis of COVID-19 by a Novel Immunogenic Secreted SARS-CoV-2 orf8 Protein." 12/01/2021 - "Translational suppression of SARS-COV-2 ORF8 protein mRNA as a Viable therapeutic target against COVID-19: Computational studies on potential roles of isolated compounds from Clerodendrum volubile leaves." 12/01/2021 - "Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients." 01/01/2021 - "This study reveals that most human metalloproteins interact with the recently discovered SARS-CoV-2 orf8 protein, whose antibodies are one of the principal markers of SARS-CoV-2 infections. "
2.	Infections 10/20/2020 - "In this study, we characterized the secretory property of a SARS-CoV-2 orf8 protein and proposed that orf8 secretion during infection facilitates early mounting of the B cell response. "
3.	Hemolysis 01/01/2022 - "SARS-CoV-2 ORF8 protein binds the porphyrin part of hemoglobin heme at the β1 chain, causing hemolysis and dysfunctional hemoglobin to reduce oxygen-carrying capacity. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Metalloproteins
3.	Antibodies
4.	B-Lymphocyte Epitopes (B-Cell Epitope)
5.	Porphyrins
6.	Oxygen (Dioxygen)
7.	Hemoglobins (Hemoglobin)
8.	Heme (Haem)