HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

portimine

spirocyclic imine from benthic dioflagellate Vulcanodinium rugosum

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - portimine: 4
- Imines: 310
  - portimine: 4
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - portimine: 4

Experts

1.	Ishibashi, Fumito: 1 article (08/2019)
2.	Izumida, Mai: 1 article (08/2019)
3.	Kubo, Yoshinao: 1 article (08/2019)
4.	Suga, Koushirou: 1 article (08/2019)
5.	Alves-de-Souza, Catharina: 1 article (02/2019)
6.	Fribley, Andrew M: 1 article (02/2019)
7.	Makris, Christina: 1 article (02/2019)
8.	Strangman, Wendy K: 1 article (02/2019)
9.	Tomas, Carmelo: 1 article (02/2019)
10.	Wright, Jeffrey L C: 1 article (02/2019)

Related Diseases

1.	Lymphoma (Lymphomas) 12/01/2016 - "In this study we show that portimine kills human Jurkat T-lymphoma cells and mouse embryonic fibroblasts (MEFs), with LC50 values of 6 and 2.5 nM respectively. "
2.	Neoplasms (Cancer) 10/01/2023 - "Notably, this total synthesis enabled a structural reassignment of portimine B and an in-depth functional evaluation of portimine A, revealing that it induces apoptosis selectively in human cancer cell lines with high potency and is efficacious in vivo in tumour-clearance models. " 02/14/2019 - "Portimine has also been shown to induce apoptosis and reduce the growth of a variety of cancer cell lines at low nanomolar concentrations. " 10/01/2023 - "Marine-derived cyclic imine toxins, portimine A and portimine B, have attracted attention because of their chemical structure and notable anti-cancer therapeutic potential1-4. " 02/14/2019 - "Further scrutiny with human oral cavity squamous cell carcinoma (OCSCC) cell lines revealed that the open ring congener was less potent than portimine A but could still lead to the accumulation of apoptotic gene transcripts, fragment genomic DNA, and reduce cancer cell proliferation in the range of 100-200 nM."
3.	Virus Diseases (Viral Diseases) 08/24/2019 - "Portimine inhibited viral infection with an 50% inhibitory concentration (IC50) value of 4.1 nM and had no cytotoxic effect on the host cells at concentrations less than 200 nM. Portimine also inhibited vesicular stomatitis virus glycoprotein (VSV-G)-pseudotyped HIV-1 vector infection. "
4.	Infections 08/24/2019 - "This analysis revealed that portimine inhibits HIV-1 vector infection before or at the reverse transcription step. " 08/24/2019 - "Portimine inhibited viral infection with an 50% inhibitory concentration (IC50) value of 4.1 nM and had no cytotoxic effect on the host cells at concentrations less than 200 nM. Portimine also inhibited vesicular stomatitis virus glycoprotein (VSV-G)-pseudotyped HIV-1 vector infection. "
5.	Squamous Cell Carcinoma of Head and Neck 02/14/2019 - "Identification of Portimine B, a New Cell Permeable Spiroimine That Induces Apoptosis in Oral Squamous Cell Carcinoma." 02/14/2019 - "Further scrutiny with human oral cavity squamous cell carcinoma (OCSCC) cell lines revealed that the open ring congener was less potent than portimine A but could still lead to the accumulation of apoptotic gene transcripts, fragment genomic DNA, and reduce cancer cell proliferation in the range of 100-200 nM."

Related Drugs and Biologics

1.	Imines
2.	DNA (Deoxyribonucleic Acid)
3.	vesicular stomatitis virus G protein