SARS-CoV-2 spike protein

Also Known As:

spike protein, SARS-CoV-2; 2019-nCoV spike glycoprotein; 2019-nCoV spike protein; COVID-19 virus S protein; COVID-19 virus spike glycoprotein; COVID-19 virus spike protein; S protein, 2019 novel coronavirus; S protein, 2019-nCoV; S protein, COVID-19 virus; S protein, SARS-CoV-2; S protein, severe acute respiratory syndrome coronavirus 2; SARS-CoV-2 S protein; coronavirus disease 2019 virus spike glycoprotein; coronavirus disease 2019 virus spike protein; coronavirus disease-19 virus spike glycoprotein; severe acute respiratory syndrome coronavirus 2 spike glycoprotein; severe acute respiratory syndrome coronavirus 2 spike protein; spike glycoprotein, COVID-19 virus; spike protein, 2019 novel coronavirus; spike protein, 2019-nCoV; spike protein, COVID-19 virus; spike protein, severe acute respiratory syndrome coronavirus 2

Networked: 712 relevant articles (29 outcomes, 72 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Membrane Fusion Proteins: 5
      - Viral Fusion Proteins: 34
        Coronavirus Spike Glycoprotein: 25
        SARS-CoV-2 spike protein: 712
  - Viral Proteins: 4250
    - Viral Structural Proteins: 171
      - Viral Envelope Proteins: 291
        Viral Fusion Proteins: 34
        Coronavirus Spike Glycoprotein: 25
        SARS-CoV-2 spike protein: 712

Experts

1.	Clancy, Chad S: 5 articles (03/2022 - 01/2021)
2.	Furuyama, Wakako: 5 articles (03/2022 - 01/2021)
3.	Gourdine, Tylisha: 5 articles (03/2022 - 01/2021)
4.	Marzi, Andrea: 5 articles (03/2022 - 01/2021)
5.	O'Donnell, Kyle L: 5 articles (03/2022 - 01/2021)
6.	Shifflett, Kyle: 5 articles (03/2022 - 01/2021)
7.	Chu, Helen Y: 5 articles (01/2022 - 11/2020)
8.	Hoffmann, Markus: 5 articles (01/2022 - 11/2020)
9.	Pöhlmann, Stefan: 5 articles (01/2022 - 11/2020)
10.	Griffin, Amanda J: 4 articles (01/2022 - 01/2021)

Related Diseases

1.	COVID-19 08/17/2022 - "The pace of advancement along with the knowhow of theoretical concepts proved to be highly effective in detecting deadly pathogens, especially the SARS-CoV-2 spike protein of the coronavirus with the onset of the (coronavirus disease of 2019) COVID-19 pandemic. " 08/01/2023 - "This inhibitory activity of Lf-Zn-NPs to target the interaction between the SARS-CoV-2 spike protein and the ACE2 receptor offers potent protection against COVID-19 outbreaks. " 12/01/2021 - "Developing safe and effective inhibitor appears an urgent need to interrupt the binding of SARS-CoV-2 spike protein with ACE2 receptor in order to reduce the SARS-CoV-2 infection. " 01/01/2022 - "Memory B-cell and antibody responses to the SARS-CoV-2 spike protein contribute to long-term immune protection against severe COVID-19, which can also be prevented by antibody-based interventions. " 07/01/2021 - "Specifically, colocalization of fluorescent labelled: SARS-CoV-2 spike protein, ACE2, and AT1R in HK-2 cells can be used to clarify the mechanism of RASi action in renal and lung epithelia, which could lead to protocols for reducing the severity of COVID-19 in both hypertensive and normotensive patients."
2.	Infections 01/01/2022 - "The findings of our study, showed that SARS-CoV-2 S protein suppressed inflammatory responses in alveolar epithelial type II cells at early stages of infection through activation of the PI3K/AKT pathway. " 10/01/2021 - "IMPORTANCE The present study was aimed at examining the underlying mechanism of extrapulmonary manifestations of SARS-CoV-2 spike protein-associated pathogenesis, with the notion that infection of the pulmonary epithelium can lead to mediators that drive endothelial dysfunction. " 01/01/2021 - "Recent studies have centered on SARS-CoV-2, demonstrating that hematopoietic stem and progenitor cells and mature immune cells may be susceptible to infection and are impacted functionally by exposure to SARS-CoV-2 Spike protein. " 11/13/2023 - "Infection rate analyses in ACE2low and GRP78high THP-1 cells showed increased uptake of pseudovirus expressing SARS-CoV-2 spike protein. " 10/01/2023 - "The RBM comprises a region within the RBD and is directly involved in the SARS-CoV-2 spike protein interaction with the host cell ACE2 receptor, during the infection mechanism and viral transmission. "
3.	Vesicular Stomatitis 12/01/2022 - "Thereafter, a replication-competent vesicular stomatitis virus pseudotyped with SARS-CoV-2 spike protein was employed to study the viral adaptation. " 11/21/2022 - "This study investigates the MNPs' effect on vesicular stomatitis virus pseudoparticles containing the SARS-CoV-2 S protein when exposed to AMF or a water bath (WB) with varying target steady-state temperatures (45, 50, and 55 °C) for different exposure times (5, 15, and 30 min). " 06/25/2022 - "Here we describe a modified protocol to generate vesicular stomatitis virus (VSV) pseudotyped with SARS-CoV or SARS-CoV-2 spike protein in high yield. " 10/26/2021 - "Using neutralization assays with authentic SARS-CoV-2 and a recombinant vesicular stomatitis virus carrying SARS-CoV-2 S protein (rVSV-SARS2), we defined a panel of potent RBD and NTD nAbs. " 10/01/2021 - "By using vesicular stomatitis virus (VSV) particles pseudotyped with the SARS-CoV-2 spike protein, we showed that lytic EBV replication enhances ACE2-dependent SARS-CoV-2 pseudovirus entry. "
4.	Lung Injury 12/01/2022 - "The soluble form of hACE2 binds SARS-CoV-2 spike protein, prevents viral entry into target cells, and ameliorates lung injury; however, its short half-life limits therapeutic utilities. " 01/01/2023 - "Here, we investigated the effect and mechanism of action of NRICM101 on improval of COVID-19-induced pulmonary injury using S1 subunit of the SARS-CoV-2 spike protein-induced diffuse alveolar damage (DAD) of hACE2 transgenic mice. " 01/01/2021 - "To that end, we intratracheally instilled the S1 subunit of SARS-CoV-2 spike protein (S1SP) in K18-hACE2 transgenic mice that overexpress human ACE2 and examined signs of COVID-19-associated lung injury 72 h later. " 01/01/2022 - "Zhang and colleagues elegantly engineered a mutant angiotensin-converting enzyme 2 (ACE2) that competitively binds SARS-CoV-2 spike protein, reduces viral uptake by human lung cells, and ameliorates SARS-CoV-2-induced lung injury in mice expressing human ACE2." 05/18/2022 - "Specifically, SARS-CoV-2 spike protein-induced MC degranulation resulted in alveolar-capillary injury, while pretreatment of pulmonary microvascular endothelial cells with antihistamines prevented adhesion junction disruption; predictably, the combination of antiviral drug remdesivir with the antihistamine loratadine, a histamine receptor 1 (HR1) antagonist, dampened viral replication and inflammation, thereby greatly reducing lung injury. "
5.	Paramyxoviridae Infections (Parainfluenza) 01/01/2023 - "Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters." 12/13/2022 - "Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters."

Related Drugs and Biologics

1.	Vaccines
2.	Antibodies
3.	Monoclonal Antibodies
4.	Glycoproteins (Glycoprotein)
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Angiotensin-Converting Enzyme 2
7.	Peptide Hydrolases (Proteases)
8.	mRNA Vaccines
9.	Interleukin-6 (Interleukin 6)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Donor Selection
4.	Aftercare (After-Treatment)
5.	Drug Substitution