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SL-176

PPM1D inhibitor. No chemical name available. Structure in source.

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organosilicon Compounds: 15
  - SL-176: 2

Experts

1.	Sakaguchi, Kazuyasu: 2 articles (11/2021 - 10/2015)
2.	Tanino, Keiji: 2 articles (11/2021 - 10/2015)
3.	Eissler, Nina: 1 article (11/2021)
4.	Fransson, Susanne: 1 article (11/2021)
5.	Gallo-Oller, Gabriel: 1 article (11/2021)
6.	Johnsen, John Inge: 1 article (11/2021)
7.	Kogner, Per: 1 article (11/2021)
8.	Martinsson, Tommy: 1 article (11/2021)
9.	Milosevic, Jelena: 1 article (11/2021)
10.	Sveinbjörnsson, Baldur: 1 article (11/2021)

Related Diseases

1.	Neuroblastoma 11/30/2021 - "SL-176 monotherapy significantly suppressed the growth of established medulloblastoma and neuroblastoma xenografts in nude mice. " 11/30/2021 - "Comparison of different inhibitors of WIP1 showed that SL-176 was the most potent compound inhibiting medulloblastoma and neuroblastoma growth and had similar or more potent effects on cell survival than the MDM2 inhibitor Nutlin-3 or the p53 activator RITA. "
2.	Neoplasms (Cancer) 10/01/2015 - "These results demonstrate that SL-176 could be a useful lead compound in the development of effective anti-cancer agents. "
3.	Medulloblastoma 11/30/2021 - "SL-176 monotherapy significantly suppressed the growth of established medulloblastoma and neuroblastoma xenografts in nude mice. " 11/30/2021 - "Comparison of different inhibitors of WIP1 showed that SL-176 was the most potent compound inhibiting medulloblastoma and neuroblastoma growth and had similar or more potent effects on cell survival than the MDM2 inhibitor Nutlin-3 or the p53 activator RITA. "
4.	Breast Neoplasms (Breast Cancer) 10/01/2015 - "Herein, we report that a specific inhibitor, SL-176 that can be readily synthesized in 10 steps, significantly inhibits proliferation of a breast cancer cell line overexpressing PPM1D and induces G2/M arrest and apoptosis. "

Related Drugs and Biologics

1.	nutlin 3