ABX-1431

a selective inhibitor of monoacylglycerol lipase

Also Known As:

1,1,1,3,3,3-Hexafluoro-2-propanyl 4-(2-(1-pyrrolidinyl)-4-(trifluoromethyl)benzyl)-1-piperazinecarboxylate; 1-Piperazinecarboxylic acid, 4-((2-(1-pyrrolidinyl)-4-(trifluoromethyl)phenyl)methyl)-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - ABX-1431: 6
  - Piperazines: 26
    - ABX-1431: 6

Experts

1.	Anderson, Lyndsey L: 1 article (01/2022)
2.	Arnold, Jonathon C: 1 article (01/2022)
3.	Bahceci, Dilara: 1 article (01/2022)
4.	Doohan, Peter T: 1 article (01/2022)
5.	Garai, Sumanta: 1 article (01/2022)
6.	Hawkins, Nicole A: 1 article (01/2022)
7.	Kearney, Jennifer A: 1 article (01/2022)
8.	Thakur, Ganesh A: 1 article (01/2022)
9.	Deng, Hui: 1 article (04/2020)
10.	Li, Weimin: 1 article (04/2020)

Related Diseases

1.	Nervous System Diseases (Neurological Disorders) 04/01/2020 - "Currently, ABX-1431, a first-in-class inhibitor of MAGL, is entering clinical phase 2 studies for neurological disorders and other diseases. " 10/25/2018 - "ABX-1431 is currently entering clinical phase 2 studies for this neurological disorder as well as for other indications, such as neuromyeltis optica and multiple sclerosis." 10/25/2018 - "Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders." 10/25/2018 - "Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders."
2.	Multiple Sclerosis 10/25/2018 - "ABX-1431 is currently entering clinical phase 2 studies for this neurological disorder as well as for other indications, such as neuromyeltis optica and multiple sclerosis."
3.	Seizures (Absence Seizure) 01/01/2022 - "GAT229 and ABX-1431 were anticonvulsant against hyperthermia-induced seizures. "
4.	Alcoholic Liver Diseases (Alcoholic Liver Disease) 05/29/2023 - "The Monoacylglycerol Lipase Inhibitor ABX-1431 Does Not Improve Alcoholic Liver Disease."
5.	Adenocarcinoma 12/23/2022 - "ABX-1431 inhibits the development of endometrial adenocarcinoma and reverses progesterone resistance by targeting MGLL." 12/23/2022 - "Finally, it was verified that ABX-1431, MGLL inhibitor, reversed progesterone resistance and enhanced the sensitivity of endometrial adenocarcinoma to progesterone both in vitro and in vivo. "

Related Drugs and Biologics

1.	Monoacylglycerol Lipases
2.	Proteins (Proteins, Gene)
3.	Progesterone
4.	Anticonvulsants (Antiepileptic Drugs)
5.	3- (2- nitro- 1- phenylethyl)- 2- phenyl- 1H- indole

Related Therapies and Procedures

1.	Induced Hyperthermia (Thermotherapy)