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SAM-760

potent and selective 5-HT6 receptor antagonist

Also Known As:

(2-methyl-1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-benzo(d)imidazole); PF-05212377

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - SAM-760: 3
  - Piperazines: 26
    - SAM-760: 3

Experts

1.	Lockwood, Peter: 2 articles (07/2018 - 01/2018)
2.	Mancuso, Jessica: 2 articles (07/2018 - 01/2018)
3.	Comery, Thomas A: 1 article (07/2018)
4.	Doran, Angela: 1 article (07/2018)
5.	Gao, Hongying: 1 article (07/2018)
6.	Obach, R Scott: 1 article (07/2018)
7.	Sawant-Basak, Aarti: 1 article (07/2018)
8.	Schildknegt, Klaas: 1 article (07/2018)
9.	Tse, Susanna: 1 article (07/2018)
10.	Bell, Joanne: 1 article (01/2018)

Related Diseases

1.

Alzheimer Disease (Alzheimer's Disease)

02/01/2023 - "PF-05212377 (SAM760) is a potent and selective 5-HT6 antagonist, previously under development for the treatment of Alzheimer's disease. "
07/01/2018 - "SAM-760 [(2-methyl-1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-benzo[d]imidazole)], a 5HT6 antagonist, was investigated in humans for the treatment of Alzheimer's disease. "
01/01/2018 - "A Phase 2 clinical trial of PF-05212377 (SAM-760) in subjects with mild to moderate Alzheimer's disease with existing neuropsychiatric symptoms on a stable daily dose of donepezil."

Related Drugs and Biologics

1.	Donepezil (Aricept)
2.	imidazole