ANNA1 antibody

a variant of IgG antibody

Also Known As:

ANNA1-IgG; Anti-Hu autoantibodies; Anti-Hu autoantibody; Anti-neuronal nuclear autoantibody 1; Antineuronal nuclear autoantibody type 1; anti-ELAVL4 autoantibodies; anti-HuD autoantibodies; anti-HuD autoantibody; anti-neuronal nuclear antibody type 1 (ANNA1)-immunoglobulin G (IgG); antineuronal nuclear antibody 1 (ANNA1)

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lennon, Vanda A: 4 articles (01/2022 - 02/2009)
2.	McKeon, Andrew: 4 articles (01/2022 - 02/2009)
3.	Pittock, Sean J: 4 articles (01/2022 - 02/2009)
4.	Dubey, Divyanshu: 2 articles (01/2022 - 01/2018)
5.	Flanagan, Eoin P: 2 articles (01/2022 - 01/2018)
6.	Smith, Carin Y: 2 articles (01/2022 - 07/2014)
7.	Bryant, Sandra C: 1 article (01/2022)
8.	Devine, Michelle F: 1 article (01/2022)
9.	Paul, Pritikanta: 1 article (01/2022)
10.	Shah, Shailee: 1 article (01/2022)

Related Diseases

1.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/01/2018 - "One hundred five patients with CRMP5-IgG neuropathy (88% smokers; 69% having cancer, most commonly small cell lung cancer [75%]) were identified and compared to 51 patients with ANNA1-IgG neuropathy, 27 with coexisting CRMP5-IgG. " 01/01/1993 - "Anti-Hu autoantibodies in high titres, as revealed with immunocytochemistry and Western blot, were present in a patient with gastrointestinal pseudo-obstruction and small-cell lung cancer (SCLC) bearing the Hu antigen. " 02/01/1998 - "We compared the human leukocyte antigen alleles found in a group of 17 patients with small-cell lung cancer (SCLC), paraneoplastic neurologic syndromes (PNS), and high titers of anti-Hu autoantibodies with those in 30 patients with SCLC but no PNS and no anti-Hu antibodies (control group). "
2.	Neoplasms (Cancer) 09/01/2014 - "To follow trafficking, we generated a specific AnnA1 antibody that targets caveolae in the tumor endothelium. " 01/01/2018 - "One hundred five patients with CRMP5-IgG neuropathy (88% smokers; 69% having cancer, most commonly small cell lung cancer [75%]) were identified and compared to 51 patients with ANNA1-IgG neuropathy, 27 with coexisting CRMP5-IgG. " 01/01/2022 - "All patients had a cancer diagnosis, and 18 (64%) patients were neural autoantibody positive including antineuronal nuclear autoantibody type 1 (ANNA-1/anti-Hu; n = 1), ANNA-2/anti-Ri (n = 1), muscle-type acetylcholine receptor (AChR; n = 6), Purkinje cell cytoplasmic antibody type 1 (PCA-1/anti-Yo; n = 1), kelch-like protein 11 (KLH11; n = 3), collapsin response mediator protein 5 (CRMP-5/anti-CV2; n = 2), α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (n = 1), neurofilament light chain (n = 1), leucine zipper 4 (LUZP4; n = 1), and unclassified neural antibodies (n = 1). "
3.	Opsoclonus-Myoclonus Syndrome (Kinsbourne Syndrome) 12/01/2013 - "Opsoclonus-myoclonus syndrome (OMS) may be associated with ANNA-1 (anti-Hu) autoantibodies. " 12/01/2016 - "Antineuronal Nuclear Autoantibody Type 1/Anti-Hu-Associated Opsoclonus Myoclonus and Epilepsia Partialis Continua: Case Report and Literature Review."
4.	Limbic Encephalitis (Paraneoplastic Limbic Encephalitis) 02/01/2009 - "Patient 3, a man aged 65 years, had paraneoplastic sensory neuronopathy, limbic encephalitis, antineuronal nuclear autoantibody type 1 (ANNA-1), and squamous cell carcinoma of the lung. " 01/01/2023 - "Ongoing seizures at last follow-up were associated with Ma2-IgG or ANNA1-IgG compared to other antibodies (p = .04), highest seizure frequency being at least daily (p = .0002), seizures on electroencephalogram (EEG; p = .03), and imaging evidence of limbic encephalitis (LE; p = .03). "
5.	Paraneoplastic Polyneuropathy 09/01/2020 - "A paraneoplastic neuropathy panel revealed anti-Hu autoantibodies. "

Related Drugs and Biologics

1.	Antibodies
2.	Proteins (Proteins, Gene)
3.	Autoantibodies
4.	Antigens
5.	amphiphysin
6.	Semaphorin-3A
7.	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)
8.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
9.	Cholinergic Receptors
10.	Ion Channels (Ion Channel)

Related Therapies and Procedures

1.	Plasma Exchange