JNJ-42165279

a potent, selective, and orally bioavailable inhibitor of fatty acid amide hydrolase

Also Known As:

1-piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-((2,2-difluoro-1,3-benzodioxol-5-yl)methyl)-; N-(4-chloro-3-pyridinyl)-4-((2,2-difluoro-1,3-benzodioxol-5-yl)methyl)-1-piperazinecarboxamide

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - JNJ-42165279: 2

Experts

1.	Bailey, Graham: 1 article (01/2021)
2.	Drevets, Wayne C: 1 article (01/2021)
3.	Grunfeld, Jennifer: 1 article (01/2021)
4.	Lachau-Durand, Sophie: 1 article (01/2021)
5.	Liebowitz, Michael R: 1 article (01/2021)
6.	Ndifor, Anthony: 1 article (01/2021)
7.	Palmer, James A: 1 article (01/2021)
8.	Pemberton, Darrel J: 1 article (01/2021)
9.	Roosen, Wendy: 1 article (01/2021)
10.	Saad, Ziad S: 1 article (01/2021)

Related Diseases

1.	Cataract (Cataracts) 01/01/2021 - "In a follow-up study to investigate the progression or resolution of the fetal lens changes, animals exposed to suprapharmacological doses of JNJ-42165279 in utero had higher incidence of nuclear cataracts as detected via slit-lamp ophthalmic examinations on postnatal days 18 to 21 and 35 to 41. " 01/01/2021 - "We conclude that fetal primary lens fiber hypertrophy and nuclear cataracts at ophthalmology, are common background changes in this rat strain that are exacerbated by in utero exposure to the FAAH inhibitor JNJ-42165279." 01/01/2021 - "Exacerbation of Background Nuclear Cataracts in Sprague-Dawley Rats in Embryo-Fetal Development Studies With JNJ-42165279, a Fatty Acid Amide Hydrolase Inhibitor."
2.	Hypertrophy 01/01/2021 - "We conclude that fetal primary lens fiber hypertrophy and nuclear cataracts at ophthalmology, are common background changes in this rat strain that are exacerbated by in utero exposure to the FAAH inhibitor JNJ-42165279."
3.	Social Phobia 01/01/2021 - "We assessed the efficacy, safety, tolerability, pharmacokinetics, and pharmacodynamics of treatment with JNJ-42165279 in subjects with social anxiety disorder (SAD). " 01/01/2021 - "The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study."

Related Drugs and Biologics

1.	fatty-acid amide hydrolase (fatty acid amide hydrolase)

Related Therapies and Procedures

1.	Slit Lamp