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5F-CUMYL-PICA

synthetic cannabinoid receptor agonist

Also Known As:

1-(5-fluoropentyl)-N-(2-phenyl-2-propanyl)-1H-indole-3-carboxamide; 1H-indole-3-carboxamide, 1-(5-fluoropentyl)-N-(1-methyl-1-phenylethyl)-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - 5F-CUMYL-PICA: 4
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 5F-CUMYL-PICA: 4

Experts

1.	Kevin, Richard C: 3 articles (01/2019 - 01/2017)
2.	Lefever, Timothy W: 3 articles (01/2019 - 01/2017)
3.	McGregor, Iain S: 3 articles (01/2019 - 01/2017)
4.	Thomas, Brian F: 3 articles (01/2019 - 01/2017)
5.	Wiley, Jenny L: 3 articles (01/2019 - 01/2017)
6.	Gamage, Thomas F: 2 articles (01/2019 - 01/2018)
7.	Ametovski, Adam: 1 article (11/2020)
8.	Banister, Samuel D: 1 article (11/2020)
9.	Connor, Mark: 1 article (11/2020)
10.	Gerona, Roy R: 1 article (11/2020)

Related Diseases

1.

Pica (Geophagia)

01/01/2017 - "The primary metabolic pathways for both compounds resulted in the formation of identical metabolites following terminal hydroxylation or dealkylation of the N-pentyl chain for CUMYL-PICA or of the 5-fluoropentyl chain for 5F-CUMYL-PICA. "
01/01/2017 - "Twenty-eight metabolites were tentatively identified for CUMYL-PICA and, coincidentally, 28 metabolites for 5F-CUMYL-PICA, primarily consisting of phase I oxidative transformations and phase II glucuronidation. "
01/01/2017 - "Incubation of CUMYL-PICA and 5F-CUMYL-PICA with rat and human liver microsomes suggested rapid metabolic clearance, but in vivo metabolism was prolonged, such that parent compounds remained detectable in rat plasma 24 h post-dosing. "
01/01/2017 - "These data provide evidence that in vivo elimination of CUMYL-PICA, 5F-CUMYL-PICA and other synthetic cannabinoids is delayed compared to in vitro modeling, possibly due to sequestration into adipose tissue. "
01/01/2017 - "In vitro and in vivo pharmacokinetics and metabolism of synthetic cannabinoids CUMYL-PICA and 5F-CUMYL-PICA."

Related Drugs and Biologics

1.	Cannabinoids
2.	methyl 2- (1- (4- fluorobenzyl)- 1H- indazole- 3- carboxamido)- 3- methylbutanoate
3.	Cannabinoid Receptors (Cannabinoid Receptor)
4.	Dronabinol (THC)
5.	Cyanides (Isocyanides)
6.	indole