177Lu-EB-PSMA-617

conjugated a truncated Evans blue (EB) molecule and DOTA chelator onto PSMA-617 (EB-PSMA-617) and labeled it with 177Lu

Networked: 4 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Naphthalenesulfonates: 2
      - Evans Blue: 1888
        177Lu-EB-PSMA-617: 4
Inorganic Chemicals: 9
- Metals: 20694
  - Rare Earth Metals: 29
    - Lanthanoid Series Elements: 301
      - Lutetium: 105
        177Lu-EB-PSMA-617: 4
- Elements: 18681
  - Rare Earth Metals: 29
    - Lanthanoid Series Elements: 301
      - Lutetium: 105
        177Lu-EB-PSMA-617: 4
  - Transition Elements: 3
    - Lutetium: 105
      - 177Lu-EB-PSMA-617: 4
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Serine Proteases: 3726
        Serine Endopeptidases: 11
        Kallikreins: 2114
        Prostate-Specific Antigen: 15321
        177Lu-EB-PSMA-617: 4
      - Endopeptidases: 633
        Serine Endopeptidases: 11
        Kallikreins: 2114
        Prostate-Specific Antigen: 15321
        177Lu-EB-PSMA-617: 4
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Seminal Proteins: 8
    - Seminal Plasma Proteins: 25
      - Prostatic Secretory Proteins: 4
        Prostate-Specific Antigen: 15321
        177Lu-EB-PSMA-617: 4
Biological Factors: 2472
- Biomarkers: 240291
  - Tumor Biomarkers: 15272
    - Prostate-Specific Antigen: 15321
      - 177Lu-EB-PSMA-617: 4
- Antigens: 143924
  - Neoplasm Antigens: 6217
    - Prostate-Specific Antigen: 15321
      - 177Lu-EB-PSMA-617: 4

Experts

1.	Chen, Xiaoyuan: 3 articles (06/2019 - 01/2018)
2.	Jacobson, Orit: 3 articles (06/2019 - 01/2018)
3.	Niu, Gang: 3 articles (06/2019 - 01/2018)
4.	Fan, Xinrong: 2 articles (06/2019 - 01/2019)
5.	Li, Fang: 2 articles (06/2019 - 01/2019)
6.	Liu, Qingxing: 2 articles (06/2019 - 01/2019)
7.	Wang, Hao: 2 articles (06/2019 - 01/2019)
8.	Wang, Jingnan: 2 articles (06/2019 - 01/2019)
9.	Zang, Jie: 2 articles (06/2019 - 01/2019)
10.	Zhu, Zhaohui: 2 articles (06/2019 - 01/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "This first-in-human study demonstrated that 177Lu-EB-PSMA-617 had higher accumulation in mCRPC and that low imaging dose appears to be effective in treating tumors with high 68Ga-PSMA-617 uptakes. " 01/01/2018 - "Remarkably, a single dose of 1.85 MBq of 90Y- or 177Lu-EB-PSMA-617 was sufficient to eradicate established PMSA+ tumors in mice. " 06/01/2019 - "Pretherapeutic 68Ga-PSMA-617 PET May Indicate the Dosimetry of 177Lu-PSMA-617 and 177Lu-EB-PSMA-617 in Main Organs and Tumor Lesions." 01/01/2019 - "When the bone metastasis tumors with comparable baseline SUVmax in the range of 10.0-15.0 were selected from the two groups for comparison, the accumulated radioactivity of 177Lu-EB-PSMA-617 was about 3.02-fold higher than that of 177Lu-PSMA-617. " 01/01/2018 - "The PK and radiotherapeutic efficacy of 90Y- or 177Lu-EB-PSMA-617 was compared to the clinically used radiopharmaceutical 90Y- or 177Lu- PSMA-617 in PC3-PIP tumor-bearing mice. "
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2019 - "First-in-human study of 177Lu-EB-PSMA-617 in patients with metastatic castration-resistant prostate cancer."
3.	Neoplasm Metastasis (Metastasis) 01/01/2019 - "When the bone metastasis tumors with comparable baseline SUVmax in the range of 10.0-15.0 were selected from the two groups for comparison, the accumulated radioactivity of 177Lu-EB-PSMA-617 was about 3.02-fold higher than that of 177Lu-PSMA-617. "
4.	Adenoid Cystic Carcinoma (Cylindroma) 08/19/2022 - "Diagnosis of Adenoid Cystic Carcinoma on 68 Ga-PSMA-617 PET-CT and Therapy With 177Lu-EB-PSMA-617 (NCT04801264, Registered 16 March 2021, retrospectively registered). " 08/19/2022 - "A pilot study of 68 Ga-PSMA-617 PET/CT imaging and 177Lu-EB-PSMA-617 radioligand therapy in patients with adenoid cystic carcinoma."

Related Drugs and Biologics

1.	Radiopharmaceuticals
2.	PSMA-617
3.	177Lu-PSMA-617

Related Therapies and Procedures

1.	Castration
2.	Therapeutics