J147

02/01/2018 - "Biological efficacy of systemic J147 treatment was confirmed by its capacity to decrease TNFα pathway activation and several other markers of neuroinflammation in the CNS. "
12/01/2023 - "J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-κB signaling pathway."
12/01/2023 - "In conclusion, J147 ameliorated the sepsis-induced depressive-like behaviors induced by neuroinflammation through attenuating the TLR4/NF-κB signaling pathway in microglia."

01/01/2021 - "The test compounds were two cognition-enhancing Alzheimer's disease drug candidates, J147 and CMS121. "
01/01/2020 - "A recent breakthrough was the discovery of J147, which targets mATPase in the treatment of Alzheimer's disease. "
11/19/2019 - "Here, two structurally distinct Alzheimer's disease (AD) drug candidates, CMS121 and J147, were used to identify a unique molecular pathway that is shared between the aging brain and AD. "
01/01/2019 - "The structure of the anti-aging agent J147 used for treating Alzheimer's disease."
01/01/2018 - "The structures of 1,4-diaryl-5-trifluoromethyl-1H-1,2,3-triazoles related to J147, a drug for treating Alzheimer's disease."

11/19/2023 - "J147, a newly developed anti-dementia drug, was shown to prevent POCD in young healthy rats, and improved early post-surgical recovery in Zucker rats. "
01/01/2018 - "Here, we discover a novel molecular link between aging and dementia through the identification of the molecular target for the AD drug candidate J147. "

12/01/2023 - "J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-κB signaling pathway."
12/01/2023 - "In conclusion, J147 ameliorated the sepsis-induced depressive-like behaviors induced by neuroinflammation through attenuating the TLR4/NF-κB signaling pathway in microglia."

06/01/2018 - "To investigate the specific molecular mechanisms and effects of curcumin derivative J147 on diabetic peripheral neuropathy (DPN). "
06/01/2018 - "A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1."