HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

PrNMI

synthetic peripherally restricted cannabinoid

Also Known As:

4-(2-(-(1E)-1((4-propylnaphthalen-1-yl)methylidene)-1H-inden-3-yl)ethyl)morpholine

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Cannabinoids: 5901
      - PrNMI: 3

Experts

1.	Spigelman, Igor: 3 articles (10/2022 - 01/2018)
2.	Largent-Milnes, Tally M: 2 articles (10/2022 - 09/2018)
3.	Vanderah, Todd W: 2 articles (10/2022 - 09/2018)
4.	Seltzman, Herbert H: 2 articles (09/2018 - 01/2018)
5.	Couture, Sarah A: 1 article (10/2022)
6.	Ji, Lipin: 1 article (10/2022)
7.	Liktor-Busa, Erika: 1 article (10/2022)
8.	Liu, Yingpeng: 1 article (10/2022)
9.	Makriyannis, Alexandros: 1 article (10/2022)
10.	Nikas, Spyros P: 1 article (10/2022)

Related Diseases

1.	Pain (Aches) 01/01/2018 - "Our results demonstrate that PRCBs exemplified by PrNMI may represent a viable option for the treatment of CIPN pain symptoms." 01/01/2018 - "In an operant task which reflects cerebral processing of pain, PrNMI also dose-dependently suppressed CIPN pain behaviors. " 09/01/2018 - "Our studies using a syngeneic murine model of CIBP show that both acute and sustained administration of a peripherally restricted CB1R agonist, 4-{2-[-(1E)-1[(4-propylnaphthalen-1-yl)methylidene]-1H-inden-3-yl]ethyl}morpholine (PrNMI), significantly alleviated spontaneous pain behaviors in the animals. "
2.	Respiratory Insufficiency (Respiratory Failure) 10/01/2022 - "Significantly, the combination of morphine with the peripheral CB1 agonist, PrNMI, attenuated morphine-induced respiratory depression. " 10/01/2022 - "Results: We show that the peripherally restricted CB1 agonist (4-{2-[-(1E)-1[(4-propylnaphthalen-1-yl)methylidene]-1H-inden-3yl]ethyl}morpholine [PrNMI] 0.3, 0.6, and 1 mg/kg) does not induce respiratory depression, while our previous studies showed that a central penetrating synthetic cannabinoid does induce respiratory depression. "
3.	Neoplasms (Cancer) 09/01/2018 - "In addition, the cancer-induced bone loss in the animals was not exacerbated by a repeated administration of PrNMI. "
4.	Hypothermia 09/01/2018 - "Furthermore, catalepsy and hypothermia, the common side effects induced by cannabinoids, were measured at the supratherapeutic doses of PrNMI tested. "
5.	Hyperalgesia 01/01/2018 - "Orally administered PrNMI also dose-dependently suppressed CIPN allodynia symptoms in both male and female rats without any CNS side effects. " 01/01/2018 - "Results show that local or systemic administration of 4-{2-[-(1E)-1[(4-propylnaphthalen-1-yl)methylidene]-1H-inden-3-yl]ethyl}morpholine (PrNMI) dose-dependently suppressed CIPN mechanical and cold allodynia. "

Related Drugs and Biologics

1.	morpholine
2.	Cannabinoids
3.	Morphine (MS Contin)