isolevuglandin

10/24/2023 - "Oxidative stress, a well-known catalyst for hypertension-related illness development, disturbs redox homeostasis, which ultimately promotes lipid peroxidation, isolevuglandin production and an inflammatory response. "
04/12/2023 - "Genetic loss of function of all immunoproteasome subunits or conditional deletion of LMP7 in dendritic cell (DCs) or endothelial cells (ECs) attenuated hypertension, reduced aortic T cell infiltration, and reduced isoLG-adduct MHC-I interaction. "
04/12/2023 - "Immunoproteasomal Processing of Isolevuglandin Adducts in Hypertension."
01/01/2022 - "Thus, isoLG adducts play an essential role in the genesis and maintenance of systemic autoimmunity and hypertension in SLE."
09/07/2023 - "Isolevuglandin formation in APCs responds to acute changes in salt intake in salt-sensitive but not salt-resistant people with hypertension, and this may be regulated by renal EET 14-15. "

01/01/2021 - "Together, these studies support the notion that association of MPO with HDL leads to lower PON1 activity in part via IsoLG-mediated modification of PON1, so that IsoLG modification of PON1 could contribute to increased risk for atherosclerosis, and blocking this modification might prove beneficial to reduce atherosclerosis."
11/01/2018 - "This review highlights evidence for the potential role of isolevuglandin modification in the disease processes, especially atherosclerosis, and some of the tools including small molecule dicarbonyl scavengers utilized to assess their contributions to disease."
01/01/2018 - "IsoLG adducts are elevated in atherosclerosis. "
12/01/2003 - "Elevated plasma levels of isoLG protein adducts are observed in subjects with atherosclerosis compared with age/gender-matched controls. "
11/01/2005 - "Elevated blood isoLG-protein levels present in atherosclerosis (AS) patients point to an independent defect that is not associated with total cholesterol levels, which results in an abnormally high level of oxidative injury in AS. "

01/01/2017 - "This study is the first to describe the biological effects of IsoLG in primary HSC, the main drivers of hepatic fibrosis. "
11/08/2022 - "In vivo, inhibition of IsoLG by a dicarbonyl scavenger reduced both albuminuria and urinary apoAI and decreased TEC and LEC injury, lymphangiogenesis, and interstitial fibrosis. "

12/01/2019 - "This was associated with marked renal inflammation and a striking accumulation of isoLG adducts in splenic DCs. "
01/01/2019 - "These data support the role of mitochondrial IsoLG in mitochondrial dysfunction and inflammation. "
11/01/2005 - "Murine plasma isoLG-protein levels increased at least 2.5-fold in response to inflammation. "
11/01/2018 - "The goal of this mini-review is to highlight some of the hypertensive stimuli and the mechanisms contributing to IsoLG-protein adduct formation leading to inflammation and hypertension."
11/01/2018 - "Mechanisms of isolevuglandin-protein adduct formation in inflammation and hypertension."

06/20/2015 - "IsoLG-PE levels were elevated in plasma of patients with familial hypercholesterolemia and in the livers of mice fed a high-fat diet to induce obesity and hepatosteatosis. "
11/01/2018 - "Our findings demonstrate that clonal TCR expansion that favors positively charged CDR3s accompanies HFD-induced obesity, which may be an antigen-driven response to isoLG accumulation in macrophages."
01/01/2021 - "These, and more specific molecular pathways, link isoLG and isoLG-adduct formation to develop a variety of pathologies, including cardiovascular diseases (atherosclerosis, hypertension, heart failure), obesity and diabetes, cancer, neurodegeneration, eye diseases (retinal degeneration and glaucoma), as well as ageing. "