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PSB-0777

locally acting A2A receptor agonist

Also Known As:

4-(2-(6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-2-ylthio)ethyl)benzenesulfonic acid

Networked: 3 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - PSB-0777: 3

Experts

1.	Hou, Yangyang: 1 article (08/2020)
2.	Luo, Shaolei: 1 article (08/2020)
3.	Ma, Tengfei: 1 article (08/2020)
4.	Shao, Wenping: 1 article (08/2020)
5.	Xiao, Chunjie: 1 article (08/2020)
6.	Zhang, Yaping: 1 article (08/2020)
7.	Antonioli, L: 1 article (01/2018)
8.	Auchampach, John A: 1 article (01/2018)
9.	Awwad, O: 1 article (01/2018)
10.	Blandizzi, C: 1 article (01/2018)

Related Diseases

1.	Body Weight (Weight, Body) 01/01/2018 - "PSB-0777, but not dexamethasone, improved body weight. "
2.	Hypotension (Low Blood Pressure) 01/01/2018 - "The present study focused on evaluating the anti-inflammatory effects of the novel poorly absorbed A2A receptor agonist PSB-0777 in a rat model of oxazolone-induced colitis as well as to evaluate its cardiovascular adverse effects, paying particular attention to the onset of hypotension, one of the main adverse effects associated with the systemic pharmacological activation of A2A receptors. "
3.	Colitis 01/01/2018 - "The present study focused on evaluating the anti-inflammatory effects of the novel poorly absorbed A2A receptor agonist PSB-0777 in a rat model of oxazolone-induced colitis as well as to evaluate its cardiovascular adverse effects, paying particular attention to the onset of hypotension, one of the main adverse effects associated with the systemic pharmacological activation of A2A receptors. "
4.	Mental Disorders (Mental Disorder) 08/01/2020 - "Our study focuses on the detailed and systematic regulation of synaptic proteins and AMPA receptors by an A2A receptor agonist, PSB-0777, which may result in both beneficial and detrimental effects on neurotransmission and neuroprotection and may contribute to the pathophysiology of psychiatric disorders related to A2A receptors. "
5.	Inflammation (Inflammations) 01/01/2018 - "PSB-0777 and dexamethasone ameliorated microscopic indexes of inflammation and reduced MPO levels. "

Related Drugs and Biologics

1.	Dexamethasone (Maxidex)
2.	AMPA Receptors (AMPA Receptor)
3.	Proteins (Proteins, Gene)
4.	Oxazolone