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5-hydroxymethylcytidine

an epigenetic modification marker of DNA and RNA

Also Known As:

5-hmrC

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Cytidine: 535
        5-hydroxymethylcytidine: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Cytidine: 535
      - 5-hydroxymethylcytidine: 2
  - Ribonucleosides: 49
    - Cytidine: 535
      - 5-hydroxymethylcytidine: 2

Experts

1.	Cao, Xiaoji: 1 article (11/2018)
2.	Chen, Qin: 1 article (11/2018)
3.	Guo, Cheng: 1 article (11/2018)
4.	Guo, Mengzhe: 1 article (11/2018)
5.	Wang, Yinsheng: 1 article (11/2018)
6.	Xie, Cong: 1 article (11/2018)
7.	Zheng, Shu: 1 article (11/2018)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 01/01/2022 - "Therefore, this study revealed that Atranorin@SPIONs induced ferroptosis of GCSCs by weakening the expression of the Xc-/GPX4 axis and the 5-hydroxymethylcytidine modification of mRNAs in the pathway, thereby achieving their therapeutic effect on gastric cancer." 01/01/2022 - "Atranorin driven by nano materials SPION lead to ferroptosis of gastric cancer stem cells by weakening the mRNA 5-hydroxymethylcytidine modification of the Xc-/GPX4 axis and its expression."
2.	Colorectal Neoplasms (Colorectal Cancer) 11/30/2018 - "By using this method, we demonstrated, for the first time, the presence of 5-hmrC in human urine, and we successfully quantified 5-mdC, 5-hmdC, 5-mrC and 5-hmrC in urine samples collected from 90 patients with colorectal cancer (CRC) and 90 healthy controls. "
3.	Neoplasms (Cancer) 11/30/2018 - "5-Methyl-2'-deoxycytidine (5-mdC), 5-hydroxymethyl-2'-deoxycytidine (5-hmdC), 5-methylcytidine (5-mrC) and 5-hydroxymethylcytidine (5-hmrC) are epigenetic marks of DNA and RNA, and aberrant levels of these modified nucleosides were found to be associated with various cancers. "

Related Drugs and Biologics

1.	Therapeutic Uses
2.	atranorin
3.	Messenger RNA (mRNA)
4.	RNA (Ribonucleic Acid)
5.	Nucleosides
6.	DNA (Deoxyribonucleic Acid)
7.	5-hydroxymethyl-2'-deoxycytidine
8.	5-methyldeoxycytidine
9.	5-methylcytidine