20Ac-ingenol 3EZ

a diterpenoid compound derived from Euphorbia kansui; has cytotoxic properties

Also Known As:

3EZ, 20Ac-ingenol; 3- O-(2' E,4' Z-decadi-enoyl)-20-O-acetylingenol; 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 11/01/2020 - "3EZ, 20Ac-ingenol strongly induced inhibition of cell proliferation and apoptosis in Jeko-1 and Panc-1 cell lines through the activation of tumor suppressor proteins and caspase 3. 3EZ, 20Ac-ingenol-induced apoptosis might occur in cells with cyclin D1 accumulation through enhancing DDR, regardless of the cancer cell type."
2.	Lymphoma (Lymphomas) 11/01/2020 - "The topoisomerase 1 catalytic inhibitor 3EZ, 20Ac-ingenol specifically induces apoptosis through the activation of ATR and the up-regulation of PTEN by enhancing the DNA damage response (DDR) in human B lymphoma (BALL-1) cells. "
3.	Leukemia 09/01/2015 - "Mechanism of the inhibition of leukemia cell growth and induction of apoptosis through the activation of ATR and PTEN by the topoisomerase inhibitor 3EZ, 20Ac-ingenol."
4.	Hepatocellular Carcinoma (Hepatoma) 03/01/2021 - "The water expelling effect evaluation of 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol and ingenol on H22 mouse hepatoma ascites model and their content differences analysis in Euphorbia kansui before and after stir-fried with vinegar by UPLC."
5.	Ascites 03/01/2021 - "The water expelling effect evaluation of 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol and ingenol on H22 mouse hepatoma ascites model and their content differences analysis in Euphorbia kansui before and after stir-fried with vinegar by UPLC."

1.	Topoisomerase Inhibitors
2.	Caspase 3 (Caspase-3)
3.	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)
4.	Cyclin D1
5.	Acetic Acid (Vinegar)
6.	ingenol