A131 compound

inhibitor of PIP4K lipid kinases; de-clusters supernumerary centrosomes in cancer cells

Also Known As:

(Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 08/05/2018 - "Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131)." 01/01/2019 - "Prodrugs of the cancer cell selective anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) are orally efficacious in a mouse model of resistant colon cancer."
2.	Colonic Neoplasms (Colon Cancer) 01/01/2019 - "Prodrugs of the cancer cell selective anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) are orally efficacious in a mouse model of resistant colon cancer."

1.	Prodrugs