sotetsuflavone

isolated from Cycas revoluta Thunb., has anti-proliferative effects on tumor cells

Also Known As:

4H-1-benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-; sotetsuflavon

Networked: 4 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        sotetsuflavone: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        sotetsuflavone: 4

Experts

1.	Hu, Yanlan: 3 articles (01/2019 - 08/2018)
2.	Liu, Tongxiang: 3 articles (01/2019 - 08/2018)
3.	Wang, Shaohui: 3 articles (01/2019 - 08/2018)
4.	Cheng, Zhekang: 2 articles (12/2018 - 08/2018)
5.	Yan, Yu: 2 articles (12/2018 - 08/2018)
6.	Lei, Tao: 1 article (01/2019)
7.	Xu, Xiaoling: 1 article (01/2019)

Related Diseases

1.	Crohn Disease (Crohn's Disease) 02/05/2023 - "Sotetsuflavone ameliorates Crohn's disease-like colitis by inhibiting M1 macrophage-induced intestinal barrier damage via JNK and MAPK signalling."
2.	Colitis 02/05/2023 - "Sotetsuflavone ameliorates Crohn's disease-like colitis by inhibiting M1 macrophage-induced intestinal barrier damage via JNK and MAPK signalling."
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/01/2018 - "Mechanistically, our study demonstrated that HIF-1α played an important role in the anti-metastatic effect of sotetsuflavone in non-small-cell lung cancer A549 cells. " 08/09/2018 - "This study investigated the mechanisms of growth inhibition, cell cycle arrest and apoptosis in non-small cell lung cancer A549 cells induced by sotetsuflavone and evaluated whether sotetsuflavone can be safely utilized by humans as therapeutic agent. " 01/01/2019 - "Sotetsuflavone Induces Autophagy in Non-Small Cell Lung Cancer Through Blocking PI3K/Akt/mTOR Signaling Pathway in Vivo and in Vitro." 12/01/2018 - "This process may be associated with both PI3K/AKT and TNF-α/NF-κB pathways, and sotetsuflavone may be efficacious in the treatment of non-small-cell lung cancer." 12/01/2018 - "Sotetsuflavone suppresses invasion and metastasis in non-small-cell lung cancer A549 cells by reversing EMT via the TNF-α/NF-κB and PI3K/AKT signaling pathway."
4.	Neoplasms (Cancer) 01/01/2019 - "Our in vivo study demonstrated that sotetsuflavone significantly inhibited the growth of xenograft model inoculated A549 tumor with high a degree of safety. " 08/09/2018 - "Sotetsuflavone is isolated from Cycas revoluta Thunb., which has biological activity against tumors. " 01/01/2019 - "Sotetsuflavone is a naturally derived and occurring flavonoid, and previous studies have demonstrated that sotetsuflavone possesses potential anti-cancer activities. " 08/09/2018 - "Sotetsuflavone may be used as a novel candidate for anti-tumor therapy in patients with lung cancer."
5.	Neoplasm Metastasis (Metastasis) 12/01/2018 - "Our data demonstrated that sotetsuflavone inhibits metastasis of A549 cells, and EMT. " 12/01/2018 - "Sotetsuflavone suppresses invasion and metastasis in non-small-cell lung cancer A549 cells by reversing EMT via the TNF-α/NF-κB and PI3K/AKT signaling pathway."

Related Drugs and Biologics

1.	Flavonoids

Related Therapies and Procedures

1.	Therapeutics