RAD140

12/15/2017 - "The current study evaluates the activity and efficacy of the oral selective AR modulator RAD140 in in vivo and in vitro models of AR/ER+ breast cancer.Experimental"
12/15/2017 - "The preclinical data presented here support further clinical investigation of RAD140 in AR/ER+ breast cancer patients. "
12/15/2017 - "Oral administration of RAD140 substantially inhibited the growth of AR/ER+ breast cancer patient-derived xenografts (PDX). "
12/15/2017 - ": RAD140 bound AR with high affinity and specificity and activated AR in breast cancer but not prostate cancer cells. "
01/01/2023 - "In this study, we evaluated the efficacy of ENZ and RAD140 in vivo and in vitro in AR+/ER+ breast cancer models, characterizing the relationship of AR and ER levels to response to AR-targeting drugs and investigating the alterations of global gene expression and chromatin binding of AR and ERα after ENZ treatment. "

12/01/2023 - "In conclusion, long-term RAD140 supplementation reduced indices of overall health and failed to improve strength in female mice, suggesting that RAD140 (at a 5mg/kg dosage) may be more detrimental than beneficial in delaying or preventing sarcopenia."
12/01/2023 - "Thus, RAD140 may be effective at treating sarcopenia. "

12/01/2023 - "Adaptive potential and strength gains were calculated to assess the efficacy of RAD140 in muscle, while frailty status and mortality risk were used to measure health span. "
12/01/2023 - "Supplementation of RAD140 increased frailty status and mortality risk in the young and adult treated groups compared to the controls (p ≤ 0.042). "
12/01/2023 - "RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice."

04/01/2014 - "In this study, we investigate the SARM RAD140 in cultured rat neurons and male rat brain for its ability to provide neuroprotection, an important neural action of endogenous androgens that is relevant to neural health and resilience to neurodegenerative diseases. "

03/29/2023 - "RAD140 may be associated with an idiosyncratic drug-induced liver injury. "
01/01/2022 - "RAD-140 Drug-Induced Liver Injury."
06/01/2020 - "We report a 52-year-old man who developed drug-induced liver injury after taking Alpha Bolic (contains RAD-140) and Alpha Elite (contains both RAD-140 and LGD-4033) supplements. "
03/29/2023 - "Novel selective androgen receptor modulators such as RAD140 may be associated with idiosyncratic drug-induced liver injury. "
03/29/2023 - "Idiosyncratic drug-induced liver injury related to use of novel selective androgen receptor modulator RAD140 (Testalone): a case report."