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Nano-PSO

nanodroplet formulation of pomegranate seed oil; has neuro-protective and anti-oxidant properties

Also Known As:

Nano-pomegranate seed oil

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Oils: 1493
  - Plant Oils: 517
    - Nano-PSO: 7
Complex Mixtures: 1906
- Biological Products
  - Plant Preparations: 622
    - Plant Oils: 517
      - Nano-PSO: 7

Experts

1.	Frid, Kati: 7 articles (04/2022 - 08/2014)
2.	Gabizon, Ruth: 7 articles (04/2022 - 08/2014)
3.	Binyamin, Orli: 6 articles (01/2022 - 08/2014)
4.	Keller, Guy: 3 articles (01/2022 - 01/2015)
5.	Larush, Liraz: 3 articles (12/2017 - 08/2014)
6.	Magdassi, Shlomo: 3 articles (12/2017 - 08/2014)
7.	Friedman-Levi, Yael: 2 articles (01/2015 - 08/2014)
8.	Ovadia, Haim: 2 articles (01/2015 - 08/2014)
9.	Har-Even, Meirav: 1 article (04/2022)
10.	Pick, Chaim G: 1 article (04/2022)

Related Diseases

1.	Demyelinating Diseases (Demyelinating Disease) 01/01/2015 - "Pathological examinations revealed that Nano-PSO administration dramatically reduced demyelination and oxidation of lipids in the brains of the affected animals, which are hallmarks of this severe neurological disease. " 01/01/2015 - "We propose that novel formulations of natural antioxidants such as Nano-PSO may be considered for the treatment of patients suffering from demyelinating diseases. "
2.	Prion Diseases (Transmissible Spongiform Encephalopathies) 12/01/2017 - "We have shown previously that Nano-PSO, a nanodroplet formulation of pomegranate seed oil, delayed progression of neurodegeneration signs when administered for a designated period of time to TgMHu2ME199K mice, modeling for genetic prion disease. " 08/01/2014 - "To test whether reduced oxidation alters disease manifestation, we treated TgMHu2ME199K mice, modeling for genetic prion disease, with Nano-PSO, a nanodroplet formulation of pomegranate seed oil (PSO). " 01/01/2022 - "As opposed to Nano-PSO, Metformin neither delayed clinical disease advance in these mice nor reduced the accumulation of sulfated glycosaminoglycans, a pathologic feature of prion disease. "
3.	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 04/23/2022 - "Nano formulation of Pomegranate seed oil [Nano-PSO (Granagard TM)] has been shown to target its active ingredient to the brain and thereafter inhibit memory decline and neuronal death in mice models of AD and genetic Creutzfeldt Jacob disease. " 12/05/2019 - "We have shown recently that long-term administration of Nano-PSO, a nanodroplet formulation of PSO, delays mitochondrial damage and disease advance in a mouse model of genetic Creutzfeldt Jacob disease (CJD). " 01/01/2022 - "Comparing anti-aging hallmark activities of Metformin and Nano-PSO in a mouse model of genetic Creutzfeldt-Jakob Disease." 01/01/2022 - "Here, we compared the clinical, pathologic and biochemical effects of Metformin to those of Nano-PSO (Granagard), a brain targeted anti-oxidant shown by us to delay disease advance in transgenic mice mimicking for genetic Creutzfeldt Jacob disease (CJD) linked to the E200KPrP mutation. "
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 12/05/2019 - "We conclude that administration of Nano-PSO results in the brain targeting of CLA, and suggest that this treatment may prevent/delay the onset of neurodegenerative diseases, such as AD and CJD."
5.	Disease Progression 11/01/2020 - "We show that while transplantation of NPCs at both initial (140 days) and advance clinical states (230 days) arrested disease progression for about 30 days, after which scores rapidly climbed to those of untreated Tgs, administration of Nano-PSO to transplanted TgMHu2ME199K mice resulted in detention of disease advance for 60-80 days, followed by a slower disease progression thereafter. "

Related Drugs and Biologics

1.	Lipids
2.	Antioxidants
3.	Metformin (Glucophage)
4.	Glycosaminoglycans
5.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
6.	punicic acid

Related Therapies and Procedures

1.	Transplantation