NSC311153

a RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma

Also Known As:

5,11-dimethyl-2-(2-(1-piperidinyl)ethyl)-6H-25-pyrido(4,3-b)carbazol-9-ol acetate

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Kumarasamy, Vishnu Muthuraj: 1 article (07/2017)
2.	Sun, Daekyu: 1 article (07/2017)

1.	Neoplasms (Cancer) 07/01/2017 - "In the present study, we also showed that the systemic administration of a water soluble NSC311153 analog in a mouse MTC xenograft model inhibited the tumor growth through RET downregulation."
2.	Papillary Thyroid Cancer 07/01/2017 - "We demonstrated the specificity of NSC311153 by using papillary thyroid carcinoma (PTC) cells, the TPC1 cell line which lacks the G-quadruplex forming sequence in the promoter region due to chromosomal rearrangement. "