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SAR218645

allosteric modulator of glutamate receptor mGluR2

Also Known As:

(S)-2-(1,1-dimethyl-indan-5-yloxymethyl)-2,3-dihydro-oxazolo(3,2-a)pyrimidin-7-one

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bergis, Olivier E: 1 article (10/2016)
2.	Black, Mark D: 1 article (10/2016)
3.	Boulay, Denis: 1 article (10/2016)
4.	Defex, Henry: 1 article (10/2016)
5.	Desvignes, Christophe: 1 article (10/2016)
6.	Featherstone, Robert: 1 article (10/2016)
7.	Griebel, Guy: 1 article (10/2016)
8.	Kongsamut, Sathapana: 1 article (10/2016)
9.	Kosley, Raymond: 1 article (10/2016)
10.	Naimoli, Vanessa: 1 article (10/2016)

Related Diseases

1.	Neurobehavioral Manifestations 10/13/2016 - "This profile positions SAR218645 as a promising candidate for the treatment of cognitive symptoms of patients with schizophrenia, in particular those with abnormal attention and sensory gating abilities." 10/13/2016 - "Results from experiments in models of the cognitive symptoms associated with schizophrenia showed that SAR218645 improved MK-801-induced episodic memory deficits in rats and attenuated working memory impairment in NMDA Nr1neo-/- mice. " 10/13/2016 - "The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia."
2.	Schizophrenia (Dementia Praecox) 10/13/2016 - "When SAR218645 was tested in models of the positive symptoms of schizophrenia, it reduced head twitch behavior induced by DOI, but it failed to inhibit conditioned avoidance and hyperactivity using pharmacological and transgenic models. " 10/13/2016 - "This profile positions SAR218645 as a promising candidate for the treatment of cognitive symptoms of patients with schizophrenia, in particular those with abnormal attention and sensory gating abilities." 10/13/2016 - "Results from experiments in models of the cognitive symptoms associated with schizophrenia showed that SAR218645 improved MK-801-induced episodic memory deficits in rats and attenuated working memory impairment in NMDA Nr1neo-/- mice. " 10/13/2016 - "The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia."

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	metabotropic glutamate receptor 2