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CM544

potent and selective inhibitor of inducible nitric oxide synthase (iNOS)

Also Known As:

N-(3-(((1-iminioethyl)amino)methyl)benzyl) prolinamide dihydrochloride; N-(3-((ethanimidoylamino)methyl)benzyl)-l-prolinamide dihydrochloride

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - CM544: 2
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Cyclic Amino Acids: 3
    - Imino Acids: 11
      - Proline: 3391
        CM544: 2

Experts

1.	Ammazzalorso, Alessandra: 1 article (01/2019)
2.	Amoia, Pasquale: 1 article (01/2019)
3.	Amoroso, Rosa: 1 article (01/2019)
4.	Cataldi, Amelia: 1 article (01/2019)
5.	De Filippis, Barbara: 1 article (01/2019)
6.	Fantacuzzi, Marialuigia: 1 article (01/2019)
7.	Gallorini, Marialucia: 1 article (01/2019)
8.	Giampietro, Letizia: 1 article (01/2019)
9.	Maccallini, Cristina: 1 article (01/2019)

Related Diseases

1.

Glioma (Gliomas)

01/24/2019 - "In the long run, CM544 leads to the dephosphorylation of p38 and to a massive cleavage of PARP-1, confirming the block of C6 rat glioma cell proliferation in the G1/S checkpoint and the occurrence of necrotic cell death."
01/24/2019 - "The Selective Acetamidine-Based iNOS Inhibitor CM544 Reduces Glioma Cell Proliferation by Enhancing PARP-1 Cleavage In Vitro."
01/01/2023 - "We included studies that investigated the impact of NOS inhibitors on glioma cells using L-NMMA, CM544, PBN, 1400W or l-NAME either alone or combined with TMZ. "
01/24/2019 - "The present work was to analyze the molecular effects of the acetamidine derivative compound 39 (formally CM544, N-(3-{[(1-iminioethyl)amino]methyl}benzyl) prolinamide dihydrochloride), a newly synthetized iNOS inhibitor, in a C6 rat glioma cell model. "

Related Drugs and Biologics

1.	NG-Nitroarginine Methyl Ester (L-NAME)
2.	omega-N-Methylarginine (NG Monomethyl L Arginine)
3.	prolinamide
4.	acetamidine