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6- ((4- chlorophenyl)methyl)- 4- hydroxy- 2,3- dihydropyridazin- 3- one

a D-amino acid oxidase inhibitor

Also Known As:

PGM030756

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Chlorobenzenes: 5
        6-((4-chlorophenyl)methyl)-4-hydroxy-2,3-dihydropyridazin-3-one: 1
  - Halogenated Hydrocarbons: 42
    - Chlorinated Hydrocarbons: 240
      - Chlorobenzenes: 5
        6-((4-chlorophenyl)methyl)-4-hydroxy-2,3-dihydropyridazin-3-one: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridazines: 11
    - 6-((4-chlorophenyl)methyl)-4-hydroxy-2,3-dihydropyridazin-3-one: 1

Experts

1.	Barnes, Matt: 1 article (11/2017)
2.	Bestwick, Michael: 1 article (11/2017)
3.	Canning, Hannah: 1 article (11/2017)
4.	Carlton, Mark: 1 article (11/2017)
5.	Ellery, Jonathan: 1 article (11/2017)
6.	Farnaby, Will: 1 article (11/2017)
7.	Fieldhouse, Charlotte: 1 article (11/2017)
8.	Fradley, Rosa: 1 article (11/2017)
9.	Harrison, Helen: 1 article (11/2017)
10.	Hazel, Katherine: 1 article (11/2017)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 11/01/2017 - "Our data and methods may be useful in understanding the effects of sodium benzoate that have been seen in clinical trials of schizophrenia and Alzheimer's disease and to support the potential clinical assessment of other DAO inhibitors, such as PGM030756, which demonstrate good enzyme occupancy and D-serine increases following administration of low oral doses."
2.	Alzheimer Disease (Alzheimer's Disease) 11/01/2017 - "Our data and methods may be useful in understanding the effects of sodium benzoate that have been seen in clinical trials of schizophrenia and Alzheimer's disease and to support the potential clinical assessment of other DAO inhibitors, such as PGM030756, which demonstrate good enzyme occupancy and D-serine increases following administration of low oral doses."

Related Drugs and Biologics

1.	Sodium Benzoate
2.	Serine (L-Serine)
3.	Enzymes