AS2717638

a lysophosphatidic acid receptor 5 (LPA5) antagonist; has analgesic effect in rats

Also Known As:

6,7-dimethoxy-2-(5-methyl-1,2-benzoxazol-3-yl)-4-(piperidin-1-ylcarbonyl)isoquinolin-1(2H)-one

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

1.	Hyperalgesia 11/01/2017 - "Further, oral administration of AS2717638 inhibited LPA5 agonist-induced allodynia in mice. " 11/01/2017 - "Similarly, AS2717638 significantly ameliorated static mechanical allodynia and thermal hyperalgesia in rat models of chronic constriction injury (CCI)-induced neuropathic pain. " 11/01/2017 - "AS2717638 also significantly improved PGE2-, PGF2α-, and AMPA-induced allodynia, while both pregabalin and duloxetine alleviated only PGE2-induced allodynia in mice. "
2.	Neuralgia (Stump Neuralgia) 11/01/2017 - "Similarly, AS2717638 significantly ameliorated static mechanical allodynia and thermal hyperalgesia in rat models of chronic constriction injury (CCI)-induced neuropathic pain. " 12/05/2022 - "Blockade of lysophosphatidic acid receptor 5 (LPA5) by a recently reported antagonist AS2717638 (2) attenuated inflammatory and neuropathic pains, although it showed moderate in vivo efficacy and its structure-activity relationships and the ADME properties are little studied. "
3.	Pain (Aches) 11/01/2017 - "AS2717638 also showed analgesic effects in a rat model of inflammatory pain. "
4.	Body Weight (Weight, Body) 08/07/2021 - "In vivo, co-injection of LPS (5 mg/kg body weight) and PF8380 (30 mg/kg body weight), or LPS/AS2717638 (10 mg/kg body weight), significantly attenuated LPS-induced iNOS, TNFα, IL-1β, IL-6, and CXCL2 mRNA expression in the mouse brain. "

1.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
2.	Pregabalin (Lyrica)
3.	Duloxetine Hydrochloride (Cymbalta)
4.	Lysophosphatidic Acid Receptors
5.	Interleukin-6 (Interleukin 6)
6.	Messenger RNA (mRNA)
7.	Analgesics (Analgesic Drugs)
8.	6- (3- (piperazin- 1- yl)propanoyl)benzo(d)oxazol- 2(3H)- one

1.	Oral Administration