hemistepsin

isolated from Hemistepta lyrata (Bunge) Bunge; has anti-inflammatory properties

Also Known As:

((3aS,5aR,7S,8aR,9R,9aR)-7-hydroxy-1,5,8-trimethylidene-2-oxo-3a,4,5a,6,7,8a,9,9a-octahydroazuleno(6,5-b)furan-9-yl) 2-(hydroxymethyl)prop-2-enoate; hemistepsin A

Networked: 8 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - hemistepsin: 8
- Lactones: 1549
  - hemistepsin: 8

Experts

1.	Cho, Il Je: 4 articles (04/2021 - 01/2018)
2.	Kim, Jae Kwang: 4 articles (04/2021 - 01/2018)
3.	Kim, Sang Chan: 4 articles (04/2021 - 01/2018)
4.	Ku, Sae Kwang: 4 articles (04/2021 - 01/2018)
5.	Kim, Eun Ok: 3 articles (04/2021 - 01/2020)
6.	Jung, Dae Hwa: 3 articles (02/2021 - 01/2018)
7.	Ki, Sung Hwan: 2 articles (04/2021 - 02/2021)
8.	Park, Sang Mi: 2 articles (04/2021 - 01/2020)
9.	Kim, Young Woo: 2 articles (12/2020 - 01/2020)
10.	Lee, Jong Rok: 2 articles (12/2020 - 01/2020)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2018 - "Hemistepsin A ameliorates acute inflammation in macrophages via inhibition of nuclear factor-κB and activation of nuclear factor erythroid 2-related factor 2." 04/29/2021 - "Hemistepta lyrata (Bunge) Bunge is a biennial medicinal plant possessing beneficial effects including anti-inflammation, and hemistepsin A (HsA) isolated from H. "
2.	Neoplasms (Cancer) 12/01/2021 - "Although hemistepsin A (HsA) is known to have anti-tumor effects, the molecular mechanisms of HsA-mediated cell death are unclear. " 01/01/2020 - "Hemistepsin A, a sesquiterpene lactone compound isolated from Hemistepta lyrata, has been identified a variety of pharmacological actions including anti-hepatotoxic, anti-inflammatory and anti-cancer activities. " 01/01/2020 - "Hemistepsin A (HsA), a natural sesquiterpene lactone isolated from Hemistepta lyrata, has been known as a wide range of anti-tumor effects. "
3.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2020 - "Hemistepsin A alleviates liver fibrosis by inducing apoptosis of activated hepatic stellate cells via inhibition of nuclear factor-κB and Akt." 02/01/2021 - "Hemistepsin A (HsA) is a guaianolide sesquiterpene lactone that inhibits hepatitis and liver fibrosis. "
4.	Hepatocellular Carcinoma (Hepatoma) 04/29/2021 - "Hemistepsin a Induces Apoptosis of Hepatocellular Carcinoma Cells by Downregulating STAT3." 01/01/2020 - "Hemistepsin A Inhibits Cell Proliferation and Induces G0/G1-Phase Arrest, Cellular Senescence and Apoptosis Via the AMPK and p53/p21 Signals in Human Hepatocellular Carcinoma."
5.	Hepatitis 01/01/2020 - "Hemistepsin A (HsA), isolated from Hemistepta lyrata (Bunge) Bunge, has the ability to ameliorate hepatitis in mice. " 02/01/2021 - "Hemistepsin A (HsA) is a guaianolide sesquiterpene lactone that inhibits hepatitis and liver fibrosis. "

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Lactones
3.	Caspase 9
4.	Caspase 3 (Caspase-3)
5.	Cytochromes c (Cytochrome c)
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Pyruvate Dehydrogenase Acetyl-Transferring Kinase