radiprodil

selective inhibitor for NMDA receptor GluN2B subunit

Also Known As:

2-(4-(4-fluoro-benzyl)-piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydro-benzooxazol-6-yl)-acetamide; 1-Piperidineacetamide, N-(2,3-dihydro-2-oxo-6-benzoxazolyl)-4-((4-fluorophenyl)methyl)-alpha-oxo-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Acetamides: 21
    - radiprodil: 3
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Acetamides: 21
        radiprodil: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - radiprodil: 3

Experts

1.	Muglia, Pierandrea: 3 articles (01/2020 - 01/2017)
2.	Sciberras, David: 2 articles (01/2020 - 01/2017)
3.	Auvin, Stéphane: 1 article (01/2020)
4.	Avbersek, Andreja: 1 article (01/2020)
5.	Collier, Jo: 1 article (01/2020)
6.	Dozières-Puyravel, Blandine: 1 article (01/2020)
7.	Kaminski, Rafal M: 1 article (01/2020)
8.	Leclercq, Karine: 1 article (01/2020)
9.	Mares, Pavel: 1 article (01/2020)
10.	André, Véronique Marie: 1 article (09/2017)

Related Diseases

1.	Infantile Spasms (West Syndrome) 01/01/2020 - "Radiprodil, a NR2B negative allosteric modulator, from bench to bedside in infantile spasm syndrome."
2.	Spasm (Spasms) 01/01/2020 - "The clinical testing, although preliminary, showed that radiprodil is associated with a good safety and pharmacokinetic profile, and with the potential to control epileptic spasms." 01/01/2020 - "After radiprodil withdrawal, the one infant continued to be spasm-free, while the two others experienced seizure worsening requiring the use of the ketogenic diet and other antiepileptic drugs. "
3.	Seizures (Absence Seizure) 01/01/2020 - "Radiprodil has been tested in three models, including pentylenetetrazole-induced seizures in rats across different postnatal (PN) ages. "
4.	Parkinson Disease (Parkinson's Disease) 01/01/2017 - "Investigate a combination of two clinically tested drugs, the NR2B antagonist Radiprodil and the A2A antagonist Tozadenant in the MPTP-treated marmoset model of Parkinson's Disease (PD). "
5.	Brain Diseases (Brain Disorder) 09/01/2017 - "Consequently, our data suggest that radiprodil may be a valuable therapeutic option for treatment of pediatric epileptic encephalopathies associated with GRIN2B mutations." 09/01/2017 - "Additionally, in the Mg2+ insensitive variants, radiprodil blocked glutamate-activated currents with the same potency as in the absence of Mg2+. The gain of function observed in the reported GRIN2B variants could be a key pathophysiological factor leading to neuronal hyper-excitability in epileptic encephalopathies. "

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
3.	Pentylenetetrazole (Metrazol)
4.	Anticonvulsants (Antiepileptic Drugs)
5.	tozadenant

Related Therapies and Procedures

1.	Ketogenic Diet