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4- (N- methyl- N- (4- (trifluoromethyl)phenyl)sulfamoyl) benzoic acid

a casein kinase 1alpha (CK1alpha) activator with antineoplastic properties

Also Known As:

SSTC3

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl) benzoic acid: 3
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - 4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl) benzoic acid: 3

Experts

1.	Capobianco, Anthony J: 2 articles (01/2019 - 06/2017)
2.	Li, Bin: 2 articles (01/2019 - 06/2017)
3.	Long, Jun: 2 articles (01/2019 - 06/2017)
4.	Orton, Darren: 2 articles (01/2019 - 06/2017)
5.	Robbins, David J: 2 articles (01/2019 - 06/2017)
6.	Rodriguez-Blanco, Jezabel: 2 articles (01/2019 - 06/2017)
7.	Shen, Chen: 2 articles (01/2019 - 06/2017)
8.	Ayad, Nagi G: 1 article (01/2019)
9.	Collins, Sara: 1 article (01/2019)
10.	Kasahara, Noriyuki: 1 article (01/2019)

Related Diseases

1.	Neoplasms (Cancer) 06/27/2017 - "Consistent with this observation, we showed that the abundance of the SSTC3 target, CK1α, was decreased in WNT-driven tumors relative to normal gastrointestinal tissue, and knocking down CK1α increased cellular sensitivity to SSTC3. " 01/01/2019 - "SSTC3 accumulated in the brain, inhibited growth of SHH medulloblastoma tumors, and blocked metastases in a genetically engineered vismodegib-resistant mouse model of SHH medulloblastoma. "
2.	Neoplasm Metastasis (Metastasis) 01/01/2019 - "Importantly, SSTC3 attenuated growth and metastasis of orthotopic patient-derived TRP53-mutant, MYCN-amplified, SHH subgroup medulloblastoma xenografts, increasing overall survival. " 01/01/2019 - "SSTC3 accumulated in the brain, inhibited growth of SHH medulloblastoma tumors, and blocked metastases in a genetically engineered vismodegib-resistant mouse model of SHH medulloblastoma. "
3.	Medulloblastoma 01/01/2019 - "Using a newly described small-molecule, SSTC3, we show that CK1a activators could address a significant unmet clinical need for patients with SMO inhibitor-resistant medulloblastoma, including those harboring mutations in TRP53." 01/01/2019 - "Importantly, SSTC3 attenuated growth and metastasis of orthotopic patient-derived TRP53-mutant, MYCN-amplified, SHH subgroup medulloblastoma xenografts, increasing overall survival. " 01/01/2019 - "SSTC3 inhibited SHH activity in vitro, acting downstream of the vismodegib target SMOOTHENED (SMO), and reduced the viability of sphere cultures derived from SHH medulloblastoma. " 01/01/2019 - "SSTC3 accumulated in the brain, inhibited growth of SHH medulloblastoma tumors, and blocked metastases in a genetically engineered vismodegib-resistant mouse model of SHH medulloblastoma. "
4.	Autoimmune Diseases (Autoimmune Disease) 09/18/2023 - "Manipulating CSNK1A1 through SSTC3 might be a potential therapeutic strategy for alleviating STING1-mediated aberrant type I IFNs in autoimmune diseases.Abbreviations" 09/18/2023 - "Importantly, pharmacological activation of CSNK1A1 using SSTC3 markedly repressed the systemic autoinflammatory responses in the trex1-/- mouse autoimmune disease model and effectively suppressed the production of IFNs and ISGs in the PBMCs of SLE patients. "

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