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LSS-11

induces apoptosis and inhibits tumor growth; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ji, Liyan: 2 articles (10/2017 - 06/2017)
2.	Li, Shasha: 2 articles (10/2017 - 06/2017)
3.	Liu, Zhongqiu: 2 articles (10/2017 - 06/2017)
4.	Meng, Xiangbao: 2 articles (10/2017 - 06/2017)
5.	Tang, Shunan: 2 articles (10/2017 - 06/2017)
6.	Yang, Simin: 2 articles (10/2017 - 06/2017)
7.	Yu, Siwang: 2 articles (10/2017 - 06/2017)
8.	Liu, Xi: 1 article (10/2017)
9.	Lu, Linlin: 1 article (10/2017)
10.	Qi, Xiaoxiao: 1 article (10/2017)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 06/06/2017 - "Finally, LSS-11 potently inhibited the growth of S180 murine sarcoma and SW480 human colorectal cancer xenografts in vivo without significant major toxicities. "
2.	Sarcoma (Soft Tissue Sarcoma) 06/06/2017 - "Finally, LSS-11 potently inhibited the growth of S180 murine sarcoma and SW480 human colorectal cancer xenografts in vivo without significant major toxicities. "
3.	Neoplasms (Cancer) 06/06/2017 - "These results suggest that LSS-11 deserves further research and development as a novel anti-cancer agent, and provided new understandings of mechanisms by which LSS-11 inhibited multiple DNA-associated processes and tumor growth."
4.	Lung Neoplasms (Lung Cancer) 10/26/2017 - "The Novel Triazolonaphthalimide Derivative LSS-11 Synergizes the Anti-Proliferative Effect of Paclitaxel via STAT3-Dependent MDR1 and MRP1 Downregulation in Chemoresistant Lung Cancer Cells." 10/26/2017 - "Collectively, our data show that LSS-11 is a potent naphthalimide-based chemosensitizer that could enhance cell death in paclitaxel-resistant lung cancer cells through the DR5/PARP1 pathway and STAT3/MDR1/MRP1 STAT3 inhibition." 10/26/2017 - "Herein, we investigated the cytotoxic effects and underlying mechanism of LSS-11, a novel naphthalimide derivative-based topoisomerase inhibitor, in paclitaxel-resistant A549 (A549/T) lung cancer cells. "
5.	Colonic Neoplasms (Colon Cancer) 06/06/2017 - "Furthermore, LSS-11 exhibited strong cytotoxicity in selected human colon cancer cell lines by inducing cell cycle arrest and apoptosis, which was accompanied by DNA damage response. "

Related Drugs and Biologics

1.	Topoisomerase Inhibitors
2.	Naphthalimides
3.	Paclitaxel (Taxol)
4.	DNA (Deoxyribonucleic Acid)
5.	multidrug resistance-associated protein 1