AG 205

a progesterone receptor membrane component 1 antagonist, ablates progesterone's ability to block oxidative stress-induced apoptosis of human granulosa/luteal cells

Also Known As:

AG-205; cis-2-((1-(4-chlorophenyl)-1H-tetrazol-5-yl)thio)-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido(4,3-b)indol-5-yl)-ethanone, cis-5-(((1-(4-chlorophenyl)-1H-tetraazol-5-yl)sulfanyl)acetyl)-2,8-dimethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido(4,3-b)indole

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - AG 205: 3

Experts

1.	Chen, Ming-Liang: 1 article (01/2022)
2.	Dong, Xun-Hu: 1 article (01/2022)
3.	He, Ying: 1 article (01/2022)
4.	Liu, Zheng: 1 article (01/2022)
5.	Xu, Ya-Li: 1 article (01/2022)
6.	Zhu, Qiong: 1 article (01/2022)
7.	Becker, Ivonne: 1 article (12/2021)
8.	Eckhardt, Matthias: 1 article (12/2021)
9.	Wang-Eckhardt, Lihua: 1 article (12/2021)
10.	Aynaci, Asena: 1 article (10/2021)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 10/06/2021 - "In conclusion, although AG-205 has attractive effects encouraging its use to develop therapeutic strategies, for instance against breast cancer, our study delivers two important warning messages. "
2.	Kidney Neoplasms (Kidney Cancer) 12/13/2021 - "Sulfatide synthesis in the human renal cancer cell line SMKT-R3 was strongly inhibited in the presence of low µM concentrations of AG-205, a progesterone receptor membrane component 1 (PGRMC1) antagonist. "
3.	Glioblastoma (Glioblastoma Multiforme) 01/01/2022 - "PGRMC1 inhibitor AG-205 or PGRMC1 siRNA pretreatment enhanced UTMD-induced LC3B2 and p62 accumulation in IR-exposed glioblastoma cells, thereby promoting UTMD-mediated radiosensitization (P < 0.05). "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Sulfoglycosphingolipids (Sulfatides)
3.	Progesterone Receptors (Progesterone Receptor)