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1-deoxysphingolipid

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Membrane Lipids: 1591
  - Sphingolipids: 3208
    - 1-deoxysphingolipid: 9

Experts

1.	Hornemann, Thorsten: 5 articles (01/2021 - 11/2015)
2.	Alecu, Irina: 3 articles (01/2021 - 11/2015)
3.	Chen, Qingfa: 2 articles (01/2021 - 01/2020)
4.	Gai, Zhibo: 2 articles (01/2021 - 01/2020)
5.	Gui, Ting: 2 articles (01/2021 - 01/2020)
6.	Kugathasan, Umaiyal: 2 articles (01/2021 - 01/2019)
7.	Kullak-Ublick, Gerd A: 2 articles (01/2021 - 01/2020)
8.	Lone, Museer A: 2 articles (01/2021 - 01/2020)
9.	Othman, Alaa: 2 articles (01/2021 - 11/2015)
10.	Reilly, Mary M: 2 articles (01/2021 - 01/2019)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 01/01/2019 - "Assessments included Charcot-Marie-Tooth Neuropathy Score version 2 (CMTNSv2), CMTNSv2-Rasch modified, nerve conduction studies, quantitative sensory testing, intraepidermal nerve fibre density (thigh), computerised myometry (lower limbs), plasma 1-deoxysphingolipid levels, calf-level intramuscular fat accumulation by MRI and patient-based questionnaires (Neuropathic Pain Symptom Inventory and 36-Short Form Health Survey version 2 [SF-36v2]). "
2.	Neoplasms (Cancer) 10/01/2022 - "1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells." 02/16/2006 - "[structure: see text] A family of cyclic 1-deoxysphingolipid derivatives of structure 4 has been designed and synthesized, which may serve as tumorigenesis suppressors for various cancers. " 11/01/2015 - "We also tested whether there is an association between peripheral neuropathy symptoms [evaluated by the European Organization for Research and Treatment of Cancer (EORTC) QLQ-chemotherapy-induced peripheral neuropathy-20 (CIPN20) instrument] and the 1-deoxysphingolipid plasma levels (measured by mass spectrometry) in 27 patients with breast cancer who were treated with paclitaxel chemotherapy. "
3.	Obesity 01/01/2021 - "We examined individual 1-deoxysphingolipid species using LC/MS/MS in plasma samples from 75 individuals including lean controls (LC, n = 19), those with obesity (n = 19), obesity with T2D without DN (ob/T2D, n = 18), and obesity with T2D with DN (Ob/T2D/DN, n = 19). " 01/01/2020 - "FXR activation by OCA protected the liver against oxidative stress, apoptosis, and reduced 1-deoxysphingolipid levels, both in a HFD-induced mouse model of obesity and in 1-deoxysphinganine-treated mice. "
4.	Hereditary Sensory and Autonomic Neuropathies (HSAN) 10/15/2019 - "Hereditary sensory and autonomic neuropathy (HSAN) types IA and IC (IA/C) are caused by elevated levels of an atypical class of lipid named 1-deoxysphingolipid (DoxSL). " 01/01/2021 - "Hereditary sensory neuropathy type 1 (HSN1) is caused by mutations in the SPTLC1 or SPTLC2 sub-units of the enzyme serine palmitoyltransferase, resulting in the production of toxic 1-deoxysphingolipid bases (DSBs). "
5.	Carcinogenesis 02/16/2006 - "[structure: see text] A family of cyclic 1-deoxysphingolipid derivatives of structure 4 has been designed and synthesized, which may serve as tumorigenesis suppressors for various cancers. "

Related Drugs and Biologics

1.	Serine C-Palmitoyltransferase
2.	Paclitaxel (Taxol)
3.	Serine (L-Serine)
4.	Lipids
5.	Enzymes
6.	Alanine (L-Alanine)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)