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ASP2408

a T-cell costimulation modulator derived from CTLA4 and wild type IgG2

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Physiological Effects of Drugs: 1
    - Immunologic Factors: 7984
      - Immunoconjugates: 3432
        ASP2408: 2
Biological Factors: 2472
- Biomarkers: 240291
  - Differentiation Antigens: 2082
    - T-Lymphocyte Differentiation Antigens: 40
      - CTLA-4 Antigen: 887
        ASP2408: 2
- Antigens: 143924
  - Surface Antigens: 5813
    - Differentiation Antigens: 2082
      - T-Lymphocyte Differentiation Antigens: 40
        CTLA-4 Antigen: 887
        ASP2408: 2

Experts

1.	Karrer, Erik E: 2 articles (11/2016 - 09/2016)
2.	Chapin, Steven J: 1 article (11/2016)
3.	Devens, Bruce H: 1 article (11/2016)
4.	Fujii, Yasutomo: 1 article (11/2016)
5.	Higashi, Yasuyuki: 1 article (11/2016)
6.	Mizuhara, Hidekazu: 1 article (11/2016)
7.	Neighbors, Margaret: 1 article (11/2016)
8.	Oshima, Shinsuke: 1 article (11/2016)
9.	Takamura, Fujiko: 1 article (11/2016)
10.	Viswanathan, Sridhar: 1 article (11/2016)

Related Diseases

1.	Rheumatoid Arthritis 09/01/2016 - "ASP2408 is a next-generation anti-cytotoxic T lymphocyte antigen-4 fusion protein engineered for improved CD86 binding affinity as a treatment for rheumatoid arthritis (RA). " 11/01/2016 - "Here we evaluated the effect of ASP2408 in vitro using cynomolgus monkey and rat T cell proliferation assays and in vivo using cynomolgus monkey tetanus toxoid (TTx) immunization and a rat rheumatoid arthritis model. "
2.	Inflammation (Inflammations) 11/01/2016 - "ASP2408 inhibited anti-TTx immunological reactions in cynomolgus monkey at a 10-fold lower dose level than belatacept, through complete CD86 and partial CD80 receptor occupancies, and also suppressed inflammation in the rat collagen-induced arthritis model. "
3.	Experimental Arthritis 11/01/2016 - "ASP2408 inhibited anti-TTx immunological reactions in cynomolgus monkey at a 10-fold lower dose level than belatacept, through complete CD86 and partial CD80 receptor occupancies, and also suppressed inflammation in the rat collagen-induced arthritis model. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Tetanus Toxoid (Vaccine, Tetanus)
3.	Abatacept (Orencia)