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2-N-(1'-carboxamidino)sphingosine

a sphingosine kinase-1 inhibitor; LCL351 is L-erythro-2-N-(1'-carboxamidino)sphingosine; structure in first source

Also Known As:

L-erythro-2-N-(1'-carboxamidino)sphingosine; LCL351

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Bai, Aiping: 1 article (01/2017)
2.	Bialkowska, Agnieszka B: 1 article (01/2017)
3.	Bielawska, Alicja: 1 article (01/2017)
4.	Coant, Nicolas: 1 article (01/2017)
5.	Hannun, Yusuf A: 1 article (01/2017)
6.	Obeid, Lina M: 1 article (01/2017)
7.	Orr-Gandy, K Alexa: 1 article (01/2017)
8.	Pulkoski-Gross, Michael J: 1 article (01/2017)
9.	Snider, Ashley J: 1 article (01/2017)
10.	Szulc, Zdzislaw M: 1 article (01/2017)

Related Diseases

1.	Splenomegaly 01/01/2017 - "In mice challenged with dextran sodium sulfate (DSS), a murine model for IBD, LCL351 treatment protected from blood loss and splenomegaly. "
2.	Neoplasms (Cancer) 05/01/2011 - "The synthesis of two agents D-erythro-2-N-(1'-carboxamidino)sphingosine hydrochloride (LCL146) and L-erythro-2-N-(1'-carboxamidino)sphingosine hydrochloride (LCL351) is described and they have been shown to inhibit SphK activity, be cytotoxic to cancer cells and decrease the migration rate of human prostate (DU145) cells."
3.	Colitis 01/01/2017 - "Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis."

Related Drugs and Biologics

1.	2-N-(1'-carboxamidino)sphingosine
2.	Dextrans (Dextran)
3.	sphingosine kinase
4.	sodium sulfate (sodium bisulfate)