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ICL-CCIC-0019

has antineoplastic activity; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - ICL-CCIC-0019: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Aminopyridines: 77
      - ICL-CCIC-0019: 1
    - Pyridinium Compounds: 5
      - ICL-CCIC-0019: 1

Experts

1.	Aboagye, Eric O: 1 article (06/2016)
2.	Adejumo, Thomas: 1 article (06/2016)
3.	Brickute, Diana: 1 article (06/2016)
4.	Carling, David: 1 article (06/2016)
5.	Carroll, Laurence: 1 article (06/2016)
6.	Favicchio, Rosy: 1 article (06/2016)
7.	Fortt, Robin: 1 article (06/2016)
8.	Gottlieb, Eyal: 1 article (06/2016)
9.	Kaliszczak, Maciej: 1 article (06/2016)
10.	Kalusa, Andrew: 1 article (06/2016)

Related Diseases

1.

Neoplasms (Cancer)

06/14/2016 - "The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth."
06/14/2016 - "Inhibition of choline kinase alpha (CHKA), the first committed step to phosphatidylcholine synthesis, by the selective small-molecule ICL-CCIC-0019, potently suppressed growth of a panel of 60 cancer cell lines with median GI50 of 1.12 μM and inhibited tumor xenograft growth in mice. "

Related Drugs and Biologics

1.	Phosphatidylcholines (Phosphatidylcholine)
2.	Choline Kinase