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(R)- 2- (4- (phenyl(3- (trifluoromethyl)phenyl)methyl)piperazin- 1- yl)acetic acid

treatment of symptoms associated with schizophrenia

Also Known As:

AMG 747; tilapertin

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - (R)-2-(4-(phenyl(3-(trifluoromethyl)phenyl)methyl)piperazin-1-yl)acetic acid: 1

Experts

1.	Buchanan, Robert W: 1 article (01/2017)
2.	Chen, Chao-Yin: 1 article (01/2017)
3.	Dietrich, Julie M: 1 article (01/2017)
4.	Dunayevich, Eduardo: 1 article (01/2017)
5.	Marder, Stephen: 1 article (01/2017)
6.	Nilsen, Jon: 1 article (01/2017)
7.	Sun, Hong: 1 article (01/2017)
8.	Yang, Jun: 1 article (01/2017)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2017 - "Adults diagnosed with schizophrenia stabilized on antipsychotic medication randomized (2:2:2:3) to orally receive daily AMG 747 (5mg, 15mg, or 40mg) or placebo. " 01/01/2017 - "Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia." 01/01/2017 - "To determine the safety and efficacy of AMG 747, an oral inhibitor of glycine transporter type-1 (GlyT1), as an add-on to antipsychotic therapy in clinically stable people with schizophrenia with enduring negative symptoms. "
2.	Stevens-Johnson Syndrome (Lyell's Syndrome) 01/01/2017 - "Studies were terminated early after a report of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) in one participant (40-mg AMG 747). "

Related Drugs and Biologics

1.	Glycine Plasma Membrane Transport Proteins
2.	Antipsychotic Agents (Antipsychotics)

Related Therapies and Procedures

1.	Therapeutics