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XMU-MP-1

protein kinase inhibitor; structure in first source

Also Known As:

4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido(5,4-b)thieno(3,2-e)(1,4diazepin-2-yl)amino)benzenesulfonamide

Networked: 20 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Huang, Zhihui: 3 articles (10/2021 - 01/2020)
2.	Shen, Xiya: 3 articles (10/2021 - 01/2020)
3.	Wang, Ying: 3 articles (10/2021 - 01/2020)
4.	Xu, Xingxing: 3 articles (10/2021 - 01/2020)
5.	Yang, Danlu: 3 articles (10/2021 - 01/2020)
6.	Zhang, Jingjing: 3 articles (10/2021 - 01/2020)
7.	Yu, Yongsheng: 2 articles (03/2022 - 01/2021)
8.	Liu, Huitao: 2 articles (10/2021 - 01/2020)
9.	Wang, Mianxian: 2 articles (10/2021 - 01/2021)
10.	Xie, Changnan: 2 articles (10/2021 - 01/2020)

Related Diseases

1.	Hypertrophy 10/01/2019 - "The Hippo pathway inhibitor, XMU-MP-1, reduced cellular hypertrophy and improved survival in cultured cardiomyocytes and, in vivo, preserved cardiac function following pressure overload." 10/01/2019 - "Here, we study the effects of pharmacological inhibition of Mst1/2 using a novel inhibitor XMU-MP-1 in controlling the adverse effects of pressure overload-induced hypertrophy. " 10/01/2019 - "XMU-MP-1 treatment significantly increased activity of the Hippo pathway effector yes-associated protein and inhibited phenylephrine-induced hypertrophy in NRCM. "
2.	Demyelinating Diseases (Demyelinating Disease) 10/05/2021 - "Finally, activation of YAP by XMU-MP-1 treatment promoted the expression of HMGCS1 in astrocytes and partially rescued the demyelination and inflammatory infiltration deficits in EAE mice. " 01/01/2021 - "Finally, activation of YAP signaling by XMU-MP-1 relieved the neuroinflammation and demyelination in optic nerve of EAE mice. "
3.	Neuroinflammatory Diseases 01/01/2021 - "Finally, activation of YAP signaling by XMU-MP-1 relieved the neuroinflammation and demyelination in optic nerve of EAE mice. " 01/01/2018 - "Both XMU-MP-1 and MST1 shRNA alleviated the neurological deficits, blood-brain barrier (BBB) disruption, brain edema, neuroinflammation, and white matter injury, which were induced by SAH in association with nuclear factor- (NF-) κB p65 and matrix metallopeptidase-9 (MMP-9) activation and downregulated endothelial junction protein expression. "
4.	Liver Failure 10/01/2023 - "With the occurrence of liver failure, plasma ALT and AST levels significantly increased, and liver function was improved in XMU-MP-1 treatment group. " 10/01/2023 - "Electron microscopy showed that mitochondria in hepatocytes of mice with liver failure became smaller and bilayer membrane density increased, while mitochondria changes in the XMU-MP-1 group were alleviated. "
5.	Inflammation (Inflammations) 01/01/2022 - "In this study, we investigated the therapeutic role of XMU-MP-1 on interleukin-1β (IL-1β)-induced inflammation in mice chondrocytes and the destabilization of the medial meniscus surgery (DMM)-induced OA model. " 12/01/2020 - "Pharmacological study using XMU-MP-1, a YAP activator, showed that activating YAP could induce anxiety-like behavior and neuro-inflammation as well as decrease hippocampal autophagy. " 03/15/2022 - "In addition, XMU-MP-1 stimulated M2 macrophage polarization and suppressed inflammation in myocardium of I/R mice. " 12/01/2020 - "Moreover, activation of YAP by XMU-MP-1 treatment attenuated the ameliorative effects of resveratrol on LPS-induced anxiety-like behavior, while blockade of YAP activation with verteporfin, a YAP inhibitor, attenuated LPS-induced anxiety-like behavior and neuro-inflammation as well as hippocampal autophagy. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Proteins (Proteins, Gene)
3.	Verteporfin (Visudyne)
4.	14-3-3 Proteins (14-3-3 Protein)
5.	Small Interfering RNA (siRNA)
6.	Integrins
7.	Interleukin-6 (Interleukin 6)
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Phenylephrine (Neo-Synephrine)
10.	Insulin (Novolin)