PMMB-187

a STAT3 inhibitor with antineoplastic activity; structure in first source

Also Known As:

1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 2-((5-(4-bromobenzyl)-1,3,4-thiadiazol-2-yl)thio)acetate

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Neoplasms (Cancer) 12/15/2017 - "Most notably, the in vivo studies further revealed that PMMB-187 could dramatically suppress the MDA-MB-231 cells xenografted tumor growth. "
2.	Breast Neoplasms (Breast Cancer) 12/15/2017 - "Furthermore, PMMB-187 inhibited constitutive/inducible STAT3 activation, transcriptional activity, nuclear translocation and downstream target genes expression in STAT3-dependent breast cancer cells MDA-MB-231. " 12/15/2017 - "By tests, PMMB-187 exhibited a more outstanding profile than shikonin on a small panel of human breast cancer cells, especially for the MDA-MB-231 cells. "

1.	shikonin