NAV-2729

a guanine nucleotide exchange factor inhibitor; structure in first source

Also Known As:

2-benzyl-3-(4-chlorophenyl)-5-(4-nitrophenyl)pyrazolo(1,5-a)pyrimidin-7(4H)-one; 3-(4-chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo(1,5-a)pyrimidin-7(4H)-one; NAV2729

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Chlorobenzenes: 5
        NAV-2729: 6
  - Halogenated Hydrocarbons: 42
    - Chlorinated Hydrocarbons: 240
      - Chlorobenzenes: 5
        NAV-2729: 6
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - NAV-2729: 6
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - NAV-2729: 6

Experts

1.	Bragazzi Cunha, J: 1 article (06/2022)
2.	El Saghir, J: 1 article (06/2022)
3.	Emmer, B T: 1 article (06/2022)
4.	Harder, J: 1 article (06/2022)
5.	Mirabelli, C: 1 article (06/2022)
6.	Sexton, J Z: 1 article (06/2022)
7.	Sherman, E J: 1 article (06/2022)
8.	Wobus, C E: 1 article (06/2022)
9.	Wotring, J W: 1 article (06/2022)
10.	Ciotkowska, Anna: 1 article (10/2021)

Related Diseases

1.	Infections 01/01/2023 - "Murine experiments demonstrated that NAV-2729 significantly alleviated mortality caused by EV71 infection. " 01/01/2023 - "Importantly, NAV-2729 also reduced SARS-CoV-2 viral loads in more physiological models of infection: Calu-3 cells and kidney organoids. " 11/07/2022 - "Importantly, NAV-2729 reduced SARS-CoV-2 viral loads also in more physiologic models of infection: Calu-3 and kidney organoids. "
2.	Virus Diseases (Viral Diseases) 01/01/2023 - "In addition, pharmacological inhibition of ARF6 with the small molecule NAV-2729 showed a dose-dependent reduction of viral infection. " 11/07/2022 - "This finding was corroborated using a pharmacologic inhibitor, whereby the ARF6 inhibitor NAV-2729 showed a dose-dependent inhibition of viral infection. "
3.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 10/01/2021 - "The presumed ADP ribosylation factor (ARF) 6 inhibitor NAV2729 inhibits human prostate smooth muscle contraction and proliferation of stromal cells, which are driving factors of voiding symptoms in benign prostatic hyperplasia (BPH). "
4.	Neoplasms (Cancer) 01/01/2018 - "ARF6 inhibition alone was not toxic; however, the ARF6 inhibitors SecinH3 and NAV2729 dramatically enhanced the killing of cancer cells by SH-BC-893 without increasing toxicity to peripheral blood mononuclear cells, suggesting that ARF6 inactivation contributes to the anti-neoplastic actions of sphingolipids. "
5.	Uveal melanoma 01/01/2023 - "NAV-2729 was previously identified as a specific inhibitor of Arf6 that reduced progression of uveal melanoma in an orthotopic xenograft. "

Related Drugs and Biologics

1.	ADP-Ribosylation Factors (ADP-Ribosylation Factor)
2.	Sphingolipids
3.	SecinH3