TUB091
a tubulin-binding compound with both antivascular and antineoplastic activities; structure in first source
Also Known As:
3-(3''-amino-4''-methoxyphenyl)-1-(5'-methoxy-3',4'-methylendioxyphenyl)-2-methylprop-2-en-1-one
Networked: 2
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
| 1. | Bueno, Oskía:
2 articles
(03/2018 - 02/2017)
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| 2. | Camarasa, María-José:
2 articles
(03/2018 - 02/2017)
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| 3. | Liekens, Sandra:
2 articles
(03/2018 - 02/2017)
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| 4. | Noppen, Sam:
2 articles
(03/2018 - 02/2017)
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| 5. | Priego, Eva-María:
2 articles
(03/2018 - 02/2017)
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| 6. | Pérez-Pérez, María-Jesús:
2 articles
(03/2018 - 02/2017)
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| 7. | Díaz, José-Fernando:
1 article
(03/2018)
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| 8. | Estévez-Gallego, Juan:
1 article
(03/2018)
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| 9. | Quesada, Ernesto:
1 article
(03/2018)
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| 10. | Tobajas, Gloria:
1 article
(03/2018)
|
Related Diseases
| 1. | Neoplasms (Cancer)
03/25/2018
- " Among the synthesized compounds, the 5-amino-6-methoxy derivative, with a similar substitution pattern to that of TUB091, showed antiproliferative activity around 20 nM against tumor and endothelial cells. " 02/28/2017
- " Accordingly, TUB091 inhibited cancer and endothelial cell growth, induced G2/M phase arrest and apoptosis at 1-10 nM. In addition, TUB091 displayed vascular disrupting effects in vitro and in the chicken chorioallantoic membrane (CAM) assay at low nanomolar concentrations. " 02/28/2017
- " We investigated the microtubule-destabilizing, vascular-targeting, anti-tumor and anti-metastatic activities of a new series of chalcones, whose prototype compound is (E)-3-(3''-amino-4''-methoxyphenyl)-1-(5'-methoxy-3',4'-methylendioxyphenyl)-2-methylprop-2-en-1-one (TUB091). "
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