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1- (((2S,3S,4S)- 3- ethyl- 4- fluoro- 5- oxopyrrolidin- 2- yl)methoxy)- 7- methoxyisoquinoline- 6- carboxamide

inhibitor of IRAK4

Also Known As:

PF-06650833

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Lactams: 2198
    - 1-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - 1-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide: 3
Organic Chemicals: 133
- Amides: 2428
  - Lactams: 2198
    - 1-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide: 3

Experts

1.	Andreyeva, Tatyana: 1 article (12/2021)
2.	Athale, Shruti: 1 article (12/2021)
3.	Barnes, Betsy J: 1 article (12/2021)
4.	Beebe, Jean J: 1 article (12/2021)
5.	Brodfuehrer, Joanne: 1 article (12/2021)
6.	Danto, Spencer I: 1 article (12/2021)
7.	De, Saurav: 1 article (12/2021)
8.	Dower, Ken: 1 article (12/2021)
9.	Fleming, Margaret: 1 article (12/2021)
10.	Gilbert, Steven A: 1 article (12/2021)

Related Diseases

1.	Pain (Aches) 01/01/2020 - "Here, we examined whether pharmacological inhibition of IRAK-4 kinase activity using PF-06650833 and BMS-986147, two clinical-stage kinase inhibitors, is effective for controlling persistent pain following nerve injury. "
2.	Lung Injury 09/01/2022 - "Unexpectedly, although both compounds had excellent IC50 on IRAK4 kinase activity, only BAY-1834845 but not PF-06650833 or high dose dexamethasone could significantly prevent lung injury according to a blinded pathology scoring. "
3.	Rheumatic Diseases (Rheumatism) 12/01/2021 - "The Interleukin-1 Receptor-Associated Kinase 4 Inhibitor PF-06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial."
4.	Inflammation (Inflammations) 12/01/2021 - "The Interleukin-1 Receptor-Associated Kinase 4 Inhibitor PF-06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial."

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