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APG-1387

a Smac mimetic with antineoplastic activity; structure in first source

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - APG-1387: 6
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - APG-1387: 6
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - APG-1387: 6

Experts

1.	Qiu, Miao-Zhen: 3 articles (03/2018 - 01/2018)
2.	Yang, Da-Jun: 3 articles (03/2018 - 01/2018)
3.	Zhang, Lin: 3 articles (03/2018 - 01/2018)
4.	Hou, Jinlin: 2 articles (01/2022 - 01/2018)
5.	Huang, Xuan: 2 articles (01/2022 - 01/2018)
6.	Liu, Hongyan: 2 articles (01/2022 - 01/2018)
7.	Zhang, Xiaoyong: 2 articles (01/2022 - 01/2018)
8.	Li, Bao-Xia: 2 articles (03/2018 - 01/2018)
9.	Luo, Qiu-Yun: 2 articles (03/2018 - 01/2018)
10.	Pan, Wen-Tao: 2 articles (03/2018 - 01/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Furthermore, APG-1387 also promoted the killing effect of Natural Killer cells on HCC cells in vitro and the combination therapy significantly inhibited tumor growth by inducing cell apoptosis in xenograft mice model. " 01/01/2018 - "The aim of this study was to investigate the anti-tumor potential of a novel bivalent SMAC mimetic, APG-1387, in hepatocellular carcinoma (HCC). " 01/01/2018 - "A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity."
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2018 - "The SMAC Mimetic APG-1387 Sensitizes Immune-Mediated Cell Apoptosis in Hepatocellular Carcinoma." 01/01/2018 - "The aim of this study was to investigate the anti-tumor potential of a novel bivalent SMAC mimetic, APG-1387, in hepatocellular carcinoma (HCC). " 01/01/2018 - "A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity."
3.	Ovarian Neoplasms (Ovarian Cancer) 03/12/2018 - "APG-1387 exhibited potent antitumor activity against established human ovarian cancer xenografts. " 03/12/2018 - "APG-1387 induced cytoprotective autophagy while triggering apoptosis in ovarian cancer cells and inhibition of autophagy enhanced APG-1387-induced apoptotic cell death. " 03/12/2018 - "APG-1387 demonstrated potent inhibitory effect on ovarian cancer cell growth and clonogenic cell survival. " 03/12/2018 - "Our results demonstrate that APG-1387 targets IAPs proteins to potently elicit apoptotic cell death in vitro and in vivo, and provide mechanistic and applicable rationale for future clinical evaluation of APG-1387 in ovarian cancer." 03/12/2018 - "Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway."
4.	Liver Cirrhosis (Hepatic Cirrhosis) 01/15/2022 - "Deletion of cIAP2 from hepatocytes or degrading cIAPs by APG-1387 ameliorated liver fibrosis induced by CCl4. " 01/15/2022 - "Liver fibrosis in CCl4-induced mouse models were investigated by Sirius red staining, RT-PCR, Western blotting after hepatocytes-specific cIAP2 knockout or IAPs inhibitor APG-1387 treatment. "
5.	Nasopharyngeal Carcinoma 10/10/2016 - "A novel Smac mimetic APG-1387 demonstrates potent antitumor activity in nasopharyngeal carcinoma cells by inducing apoptosis."

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Caspase 8 (Caspase-8)
3.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics