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VB-703

a lecinoxoid that is a TLR-4 antagonist; structure in first source

Also Known As:

1-(2-octyl)dodecyl-2-(4'-carboxy)butyl-glycero-sn-3-phosphoric acid pyridiniumethyl ester

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Breitbart, Eyal: 2 articles (02/2019 - 01/2016)
2.	Ishai, Eti: 2 articles (02/2019 - 01/2016)
3.	Mendel, Itzhak: 2 articles (02/2019 - 01/2016)
4.	Yacov, Niva: 2 articles (02/2019 - 01/2016)
5.	Feldman, Boris: 1 article (02/2019)
6.	Volkov, Alexander: 1 article (02/2019)
7.	Shoham, Anat: 1 article (01/2016)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2016 - "However, whereas VB-201 inhibited the development of fibrosis and, to some extent, liver inflammation, VB-703 significantly lessened both liver inflammation and fibrosis. " 02/01/2019 - "VB-703 attenuated the expression of fibrosis hallmark genes collagen, fibronectin (FN) and transforming growth factor β (TGF-β) in kidneys and improved albumin/creatinine ratio with higher efficacy than did VB-201, but only VB-201 significantly reduced the number of glomerular and interstitial monocytes. "
2.	Sclerosis 02/01/2019 - "The percentage of damaged glomeruli, glomerular sclerosis and glomeruli fibrotic score was significantly reduced following VB-201 and VB-703 treatment. "
3.	Inflammation (Inflammations) 01/01/2016 - "However, whereas VB-201 inhibited the development of fibrosis and, to some extent, liver inflammation, VB-703 significantly lessened both liver inflammation and fibrosis. "

Related Drugs and Biologics

1.	1- palmityl- 2- (4- carboxybutyl)- sn- glycero- 3- phosphocholine
2.	Transforming Growth Factors (Transforming Growth Factor)
3.	Fibronectins (Fibronectin)
4.	Creatinine
5.	Collagen
6.	Albumins