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ralinepag

a prostacyclin receptor agonist; structure in first source

Also Known As:

2-((4-(((4-chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - ralinepag: 3
    - Carbamates: 945
      - ralinepag: 3
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Acetates: 4994
      - ralinepag: 3

Experts

1.	Adams, John W: 2 articles (04/2020 - 01/2017)
2.	Cabell, Christopher H: 1 article (04/2020)
3.	Grundy, John S: 1 article (04/2020)
4.	King, Christopher D: 1 article (04/2020)
5.	Adams, John: 1 article (10/2019)
6.	Cabell, Christopher: 1 article (10/2019)
7.	D'Souza, Gwyn: 1 article (10/2019)
8.	Escribano Subías, Pilar: 1 article (10/2019)
9.	Farber, Harrison: 1 article (10/2019)
10.	Grundy, John: 1 article (10/2019)

Related Diseases

1.	Pulmonary Arterial Hypertension 04/01/2020 - "Ralinepag (APD811), an oral, potent, and selective prostacyclin receptor (IP) agonist is being developed for treatment of pulmonary arterial hypertension. " 10/01/2019 - "This phase 2 study was designed to assess the efficacy, safety and tolerability of immediate-release orally administered ralinepag, a selective, non-prostanoid prostacyclin receptor agonist with a 24-h terminal half-life, compared to placebo in adult patients with symptomatic pulmonary arterial hypertension (PAH). " 01/01/2017 - "Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension."
2.	Vomiting 04/01/2020 - "In the single ascending dose study, ralinepag was tolerated up to 100 µg (single dose), but not 200 µg due to nausea and vomiting. "
3.	Nausea 04/01/2020 - "In the single ascending dose study, ralinepag was tolerated up to 100 µg (single dose), but not 200 µg due to nausea and vomiting. "

Related Drugs and Biologics

1.	Epoprostenol Receptors
2.	Prostaglandins
3.	Acetates (Acetic Acid Esters)