SmacN7 peptide

consists of the first seven N-terminal residues of Smac (second mitochondrial activator of caspase)

Also Known As:

AVPIAQK; Ala-Val-Pro-Ile-Ala-Qln-Lys; alanyl-valyl-prolyl-isoleucyl-alanyl-glutaminyl-lysine

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - SmacN7 peptide: 4

Experts

1.	Feng, Zujian: 1 article (01/2020)
2.	Huang, Pingsheng: 1 article (01/2020)
3.	Li, Qinghua: 1 article (01/2020)
4.	Liu, Jianfeng: 1 article (01/2020)
5.	Liu, Jinjian: 1 article (01/2020)
6.	Wang, Weiwei: 1 article (01/2020)
7.	Zhang, Yumin: 1 article (01/2020)
8.	Fan, Rangrang: 1 article (01/2017)
9.	Gao, Xiang: 1 article (01/2017)
10.	Guo, Gang: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "Additionally, the SmacN7 peptide conjugated with cell membrane-permeable oligosarginine (denoted as SmacN7-R9) was used to enhance the radiosensitivity of cancer cells, as confirmed by the results of reactive oxygen species detection, DNA damage assay, cell apoptosis assay, and clonogenic evaluation. " 04/22/2015 - "It contained three parts, a SmacN7 peptide which could induce apoptosis of cancer cells by interacting with XIAPs, the cell penetrating domain rich in arginine, and four hydrophobic tails for self-assembled Smac-NP. " 01/01/2017 - "In this study, by fusing HAV and the classical tumor-targeting Arg-Gly-Asp (RGD) motif and Asn-Gly-Arg (NGR) motif to the apoptosis-inducing peptide sequence-AVPIAQK, a bifunctional peptide has been constructed with enhanced tumor targeting and apoptosis effects. "
2.	Hyperplasia 01/01/2016 - "Caspase 3/7 apoptosis tests after induction of apoptosis with staurosporine or UV irradiation showed that the coupling of SmacN7 with undecylic aldehyde resulted in a greatly increased adjuvant pro-apoptotic effect compared to the separate components and a mutant SmacN7 peptide sequence in the LNCaP prostate carcinoma cells compared to the benign prostate hyperplasia (BPH) cells and the human embryonal kidney (HEK) cells."
3.	Carcinoma (Carcinomatosis) 01/01/2016 - "Caspase 3/7 apoptosis tests after induction of apoptosis with staurosporine or UV irradiation showed that the coupling of SmacN7 with undecylic aldehyde resulted in a greatly increased adjuvant pro-apoptotic effect compared to the separate components and a mutant SmacN7 peptide sequence in the LNCaP prostate carcinoma cells compared to the benign prostate hyperplasia (BPH) cells and the human embryonal kidney (HEK) cells."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	NGR peptide
3.	arginyl-glycyl-aspartic acid
4.	Caspase 3 (Caspase-3)
5.	Staurosporine
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Arginine (L-Arginine)
8.	undecanal